Lung Carcinomas Flashcards
Virtually all ______ has metastasized by the time of diagnosis
Small cell lung carcinomas
_______ carcinoma of the lung is strongly associated with smoking
Squamous cell carcinoma and small cell carcinoma (99% of small cell cancer is associated with cigarette smoking)
what is the MOA of crizotinib?
protein kinase inhibitor that inhibits EML4/ALK fusion protein found in 45% of NSCLC patients
99% of ________ carcinoma is associated with cigarette smoking
small cell carcinoma
Grading of adenocarcinoma is based on the ratio of:
Glands to solid elements. More glands = better differentiated
large cell carcinoma is diagnosed via _____
exclusion: no feature of small cell carcinoma, no gland differential or squamous differentiation
which lung carcinomas are located centrally?
squamous cell and small cell carcinoma and carcinoid tumor of the lung
Cavitations are seen in what lung carcinoma?
Squamous cell carcinoma;
Cavitation due to central necrosis emptying into the airways during cough
what is the difference between the typical and atypical variant of carcinoid tumor
typical variant does not have necrosis and has little mitosis while typical has necrosis
patients with which disease would you give tyrosine inhibitors such as _____ or ______
gefitinib or erlotinib;
give to patients with advanced lung carcinomas and test positive for EGFR mutation
people with advanced lung carcinomas who test positive for the ______ mutation are more likely to respond to treatment with ____________
tyrosine kinase inhibitors such as: gefitinib and erlotinib
What are the common non small cell lung cancers?
- adenocarcinoma
- Squamous cell carcinoma
- Large cell carcinoma
what are examples of drugs that are tyrosine kinase inhibitors
gefitinib and erlotinib
large cell carcinomas have _______ prognosis
poor
Proliferation of ________ is seen in atypical adenomatous hyperplasia (precursor lesion of adenocarcinoma of lung)
Minimally atypical pneumocytes
