Blood and Lymphatic Infections Flashcards
B. quintana causes ______ and is transmitted by _____
Trench fever; body louse (lice) so expect in homeless people with poor hygiene
transmission of yersinia pestis occurs due to ____
bite of an infected flea or contact with infected animals (bubonic or septicemic plague)
what is the function of yersiniabactin LPS
- iron uptake for the bacteria to grow
what are some virulence factors associated with Y. pestis?
- Pla protease:
- murine toxin
- V antigen: anti-phagocytic factor
- F1 envelope antigen: stimulates intense immune response
- yersiniabactin LPS: iron uptakes e
the causal agent of Carrion’s disease is _______ and is transmitted via _____
B. bacilliformis; sand fly
secondary pneumonic plague is acquired via _______
hematogenous spread of Y. pestis form buboes
a homeless patient presents with symptoms of fever, headache with retro orbital pain, restlessness and severe back and shin pain. He says it occurs ever 5-6 days. explain the periodicity of his symptoms
this is caused by B. Quintana which is spread via lice.
the recurring symptoms corresponds with the release of B. quintana in the blood
describe some symptoms in someone with Ebola
- fever, headache, joint and muscle aches, sore throat, weakness followed by diarrhea, vomiting and stomach pain
- exanthems (hemorrhagic rash over the entire body)
what are the types of plague?
- bubonic
- primary pneumonic
- septicemic
B. bacilliformis can be found in what structures in the body?
RBC’s or endothelial cells
natural reservoirs for Yersinia pestis is _______
rodents; humans are accidental hosts
this is a zoonotic disease
describe the clinical manifestation of the septicemic plague
- “purpuric lesions” in the skin that turns deep shade of purple due to DIC
- altered mental status
- gangrene of extremities gives it the name “Black Death”
- multiorgan failure
in additional to the regional lymphadenopathy, what other symptoms would you expect to see in cat scratch disease?
- fever, malaise, headache, joint pain, back pain, arthritis
what are some common manifestations of B. quintana infection in densely populated, poverty stricken people?
culture negative endocarditis and septicemia
Carrion’s disease is transmitted via ______
sand fly
what is the geographical distribution of outlets of the plague caused by ____
yersinia;
New Mexico, Arizona, Colorado, California
bacillary angiomatosis is associated with ________
B. henselae and B. quintana in immunocompromised people such as those with advanced HIV
filoviruses such as _____ replicate in the _____ of the cell
Ebola virus; cytoplasm
B. henselae infection in an immunocompromised person results in _____
baciillary angiomatosis
Bartonella is transmitted by vectors such as:
ticks, fleas, sand flies and mosquitoes
describe the biology of Bartonella
- gram negative, facultative intracellular in RBC’s and endothelial cells
- B. henselae: non motile
- B. bacilliformis: motile
“safety pin” appearance on media is descriptive of _____
Yersinia; due to polyphosphate granules found on the ends
what is the function of the Pla protease in ________
- has both coagulase activity and plasmin activity
- blocks the midgut so the flea is unable to feed so the flea will be more aggressive for a blood meal
what are the clinical manifestations of someone with bubonic plague
caused by Y. pestis
- abrupt onset of high fever w/ chills
- tender and enlarged lymph nodes: “buboes” and the femoral and inguinal lymph nodes are the most common
- bubonic form can result into secondary pneumonic form
