Liver 1

Question 1

Functions of stellate cells

Answer 1

Storage of vitamin A + Production of collagen

Question 2

The commonest cause of fatty liver disease in western world is?

Answer 2

ALD

Question 3

How does alcohol produce liver injury?

Answer 3

Fatty liver => High acetaldehyde => injured hepatocytes.

+ Stimulation of collagen synthesis leads to fibrosis.

Question 4

How does liver injury occur in NAFLD?

Answer 4

• Hepatic fat accumulation.

- Hepatic oxidative stress.

Question 5

Hepatic lipid perioxidation occurs in?

Answer 5

NAFLD

Question 6

AST + ALT are elevated in 90% of patients with?

Answer 6

NASH

Question 7

The most reliable diagnostic tool for NAFLD and NASH

Answer 7

Liver biopsy

Question 8

Which type of steatosis is more common?

• Macrovesicular.
• Microvesicular.

Answer 8

Macrovesicular

Question 9

Hepatocyte swelling (ballooning) + necrosis + mallory bodies + cytokeratin seen as eosinophilic cytoplasmic lumps are seen in ?

• Steatohepatitis.
• Steatosis.
• Cirrhosis.
• All of the above.

Answer 9

Steatohepatitis

Question 10

Fibrosis in Steatohepatitis is most commonly?

• Peri portal.
• Peri venular and sinusoidal.
• There is No fibrosis in Steatohepatitis.

Answer 10

B

Question 11

Bridging fibrosis is a microscopic feature of?

Answer 11

Steatohepatitis

Question 12

Bridging fibrous septa + Parenchymal nodules + Disruption of the architecture of the entire liver are the main morphological Characteristics of ?

Answer 12

Cirrhosis

Question 13

Which of the following will not cause a micronodular (<= 3mm) cirrhosis?

• Apha 1 antitrypsin deficiency.
• Alcoholism.
• Hemochromatosis.
• Chronic viral hepatitis.

Answer 13

D ( also drugs)

Question 14

A stain that is used to stain collagen fibers

Answer 14

Masson Trichrome

Question 15

Viruses that are associated with hepatitis

Answer 15

CMV + EBV

Question 16

Enlarged red liver + ballooning + necrosis + cytolysis + apoptosis + mononuclear cells

Answer 16

Acute hepatitis

Question 17

Portal mononuclear infiltration + interface hepatitis occurs in?

Answer 17

Chronic hepatitis

Question 18

Ground glass is a characteristic of ?

Answer 18

Chronic Hepatitis B

Question 19

Fatty change + lymphoid follicles are seen in?

Answer 19

Chronic hepatitis C

Question 20

Autoimmune hepatitis autoantibodies

Answer 20

ANA + ASMA + LKM

Question 21

Plasma cells predominance + extensive interface hepatitis + hepatocytes rosette

Answer 21

Autoimmune hepatitis

Question 22

Iron is dark in …….. stain and blue in ……..stain.

Answer 22

H and E, Prussian blue

Question 23

Autosomal recessive disorder caused by mutation of the ATP7B gene

Answer 23

Wilson disease

Question 24

Glycogenated nuclei are seen in?

Answer 24

Wilson disease

Question 25

Periodic acid schiff stain (PAS) is used to stain?

Answer 25

Alpha 1 antitrypsin

Question 26

Gland forming malignant tumor

Answer 26

Cholangiocarcinoma