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Pathology > Hematology 2 > Flashcards

Hematology 2 Flashcards

1
Q

Q: which of the following causes microcytic anemia?

  • B12 deficiency.
  • Aplastic anemia.
  • Anemia of renal disease.
  • Anemia of Chronic disease.
A

Anemia of chronic disease

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2
Q

Q: Angular cheilosis and koilonychia are characteristics of which of the following?

  • Chronic IDA.
  • Aplastic anemia.
  • Thalassemia.
  • B12 deficiency.
A

Chronic IDA

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3
Q

Q: Plummer vinson syndrome is associated with?

  • SCD.
  • Lymphoma.
  • Thalassemia.
  • Chronic IDA.
A

Chronic IDA

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4
Q

Q: Prussian blue stain is used to diagnose?

  • Thalassemia.
  • IDA.
  • Sideroblastic anemia.
  • Aplastic anemia.
A

IDA

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5
Q

Q: Which of the following is the most common anemia in hospitalized patients?

  • IDA.
  • ACD.
  • SC anemia.
  • Aplastic anemia.
A

Anemia of chronic disease

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6
Q

Q: which type of anemias is associated with release of hepcidin from the liver?

  • ACD.
  • IDA.
  • SC anemia.
  • Aplastic anemia.
A

Anemia of chronic disease

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7
Q

Q: Which of the following anemias is associated with iron accumulation in the mitochondria?

  • IDA.
  • ACD.
  • Sideroblastic anemia.
  • Aplastic anemia.
A

Sideroblastic anemia

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8
Q

Q: Pyredoxine (B6) deficiency is associated with?

  • IDA.
  • ACD.
  • Sideroblastic anemia.
  • Aplastic anemia.
A

Sideroblastic anemia

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9
Q

Q: Which of the following anemias is most commonly caused by chronic alcoholism?

  • IDA.
  • ACD.
  • Sideroblastic anemia.
  • Aplastic anemia.
A

Sideroblastic anemia ( in 30% of hospitalized ch.alcoholics )

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10
Q

Q: A patient with TB and under Isoniazid. Which of the following anemias can be suspected?

  • IDA.
  • ACD.
  • Sideroblastic anemia.
  • Aplastic anemia.
A

Sideroblastic anemia

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11
Q

Q: course basophilic stippling of RBCs is a clinical feature of?

  • B6 deficiency.
  • lead poisoning.
  • ALA synthase deficiency.
  • Ferrochelatse overload.
A

Lead poisoning (due to denatured ribonuclease) => causing Sideroblastic anemia.

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12
Q

Q: Thalassemia is characterized by?

  • Autosomal dominant.
  • Autosomal recessive.
  • X linked.
  • Non of the above.
A

Autosomal recessive

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13
Q

Q: alpha thalassemia is caused by?

  • Gene deletions.
  • Point mutation.
  • Gene translocation.
  • Non of the above.
A

Gene deletions (4 genes in ch. 16 controls alpha chains)

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14
Q

Q: which of the following will show normal Hb electrophoresis?

  • SCA.
  • Alpha thalassemia trait.
  • Hb H disease.
  • Hb Bart disease.
A

Alpha thalassemia trait

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15
Q

Q: Beta thalassemia is characterized by?

  • Gene deletion.
  • Point mutation.
  • Gene translocation.
  • Non of the above.
A

Point mutation (2 genes in ch. 11 controls B chains)

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16
Q

Q: Which type of anemias might be present during pregnancy?

  • Microcytic anemia.
  • Normocytic anemia.
  • Macrocytic anemia.
  • All of the above.
A

Macrocytic anemia

17
Q

Q: Non megaloblastic anemia is caused by?

  • B12 deficiency.
  • Lead poisoning.
  • Iron deficiency.
  • Alcohol liver disease.
A

Alcohol live disease.

18
Q

Q: Hypersegmented neutrophils in the peripheral blood smear is a characteristic of?

  • B12 and folate deficiency.
  • Sideroblastic anemia.
  • Aplastic anemia.
  • ACD.
A

B12 and folate deficiency

19
Q

Q: which of the following is the most common cause of B12 deficiency?

  • Gastrectomy.
  • Pernicious anemia.
  • Chronic pancreatitis.
  • Celiac disease.
A

Pernicious anemia

20
Q

Q: In which of the following there will be high levels of homocysteine?

  • B12 and folate deficiency.
  • IDA.
  • Aplastic anemia.
  • Sideroblastic anemia.
A

B12 and folate deficiency

21
Q

Q: Accumulation of which of the following causes demyelination of nerve fibers?

  • Succinyl CoA.
  • Methylmalonyl CoA.
  • Propionyl CoA.
  • All of the above.
A

Propionyl CoA (Increased in B12 deficiency)

22
Q

Q: Increased levels of methylmalonic acid in the urine is a clinical manifestation of?

  • B12 deficiency only.
  • Folate deficiency only.
  • Both B12 and folate deficiency.
  • Non of the above.
A

B12 deficiency only

23
Q

Q: Production of succinyl CoA is inhibited in?

  • IDA.
  • Sideroblastic anemia.
  • Folate deficiency.
  • B12 deficiency.
A

B12 deficiency

24
Q

Q: RBCs in B12 deficiency are?

  • Microcytic hypochromic.
  • Macrocytic normochromic.
  • Macrocytic hypochromic.
  • Normocytic normochromic.
A

Macrocytic normochromic

25
Q

Q: Hydroxycobalamin is used to treat?

  • IDA.
  • Aplastic anemia.
  • Pernicious anemia.
  • Sideroblastic anemia.
A

Pernicious anemia

26
Q

Q: Which of the following anemias can be caused by overexposure to benzene?

  • Aplastic anemia.
  • Sideroblastic anemia.
  • IDA.
  • Megaloblastic anemia.
A

Aplastic anemia

27
Q

Q: “Dry tap” BM aspiration is a clinical feature of?

  • Aplastic anemia.
  • IDA.
  • Sideroblastic anemia.
  • Megaloblastic anemia.
A

Aplastic anemia (there will be also fat cells occupying 90% of the BM)

28
Q

Q: Pancytopenia is present in which of the following?

  • Aplastic anemia.
  • Megaloblastic anemia.
  • IDA.
  • A and B.
A

A and B

29
Q

Q: Thymoma and Parvovirus 19 infection are causes of?

  • Aplastic anemia.
  • Pure red cell aplasia.
  • IDA.
  • Megaloblastic anemia.
A

Pure red cell aplasia

30
Q

Q: Leukoerythroblastic picture of the BM is a clinical feature of?

  • Aplastic anemia.
  • Myelophthisic anemia.
  • IDA.
  • Non of the above.
A

Myelophthisic anemia ( causes: TB, metastatic cancer, myelofibrosis)

31
Q

Q: In which type of the following anemias is characterized by “Burr cells” (RBCs with undulating membrane)?

  • Aplastic anemia.
  • Anemia of chronic renal failure.
  • Sideroblastic anemia.
  • Thalassemia.
A

Anemia of CRF

32
Q

Q: Hereditary spherocytosis is?

  • Autosomal dominant disorder.
  • Autosomal recessive disorder.
  • X linked.
  • Y linked.
A

Autosomal dominant

33
Q

Q: Increased osmotic fragility test is seen in?

  • Aplastic anemia.
  • HS.
  • PNH.
  • IDA.
A

HS

34
Q

A: In which of the following there is a loss of anchor protein to decay accelerating factor (DAF) ?

  • HS.
  • PNH.
  • SC anemia.
  • Aplastic anemia.
A

PNH

35
Q

Q: Sugar water test and Positive Ham (acid serum) test are used to diagnose?

  • HS.
  • PNH.
  • Sideroblastic anemia.
  • IDA.
A

PNH

Pathology (24 decks)

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