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Pathology > CNS 2 > Flashcards

CNS 2 Flashcards

1
Q

The usual mode of transmission of meningococcal meningitis is?

  • Droplet inhalation.
  • Contact.
A

A

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2
Q

The most common organism causing meningitis in children and adults?

A

Meningococcal , pneumococcal

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3
Q

The causative organism in neonates

A

E. Coli

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4
Q

Meningitis with predominant lymphocytes in CSF + negative bacterial culture is called

A

Aseptic meningitis

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5
Q

Which of the following drugs is NOT a risk factor for meningitis?

  • Amoxicillin.
  • NSAIDs.
  • Methotrexate.
  • Azathioprine.
A

D

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6
Q

Common organisms causing viral meningitis?

A

Enterovirus - Polio virus

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7
Q

Thickened and slightly opaque pia matter indicates ?

  • Acute meningitis.
  • Chronic meningitis.
A

B

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8
Q

How does steroids causes temporary relief in primary CNS tumors?

A

Relief the peritumoral edema

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9
Q

The commonest CNS tumor?

  • Astrocytoma grade I-IV.
  • Oligodendroglioma.
  • Ependymoma.
  • Meningioma.
A

A

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10
Q

Most primary CNS tumors in adults are?

  • Supratentorial.
  • Infratentorial.
A

A

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11
Q

Butterfly tumor of the CNS?

A

Grade IV astrocytoma (Glioblastoma)

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12
Q

Usually arises in the white matter of the cerebrum

A

Grade IV astrocytoma

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13
Q

Tan solid, focally necrotic and hemorrhagic + distinct margins

A

Glioblastoma multiforme

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14
Q

Appear poorly defined grossly?

A

Diffuse fibrillary astrocytoma

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15
Q

Has better prognosis ?

  • Glioblastoma multiforme.
  • Diffuse fibrillary astrocytoma.
A

B

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16
Q

Mostly occurs in children and young?

A

Pilocytic astrocytoma ( grade 1 astrocytoma)

17
Q

Grossly: has cystic with a mural nodule

A

Pilocystic astrocytoma

18
Q

In pilocystic astrocytoma the compact areas consist of ……… and the loose areas consist of………?

A

Compact: Pilocystic astrocytes.
Loose: Rosenthal fibers.

19
Q

A primary CNS tumor occurs mostly in children?

A

Medulloblastoma

20
Q

Affects the cerebellum (vermis) + soft and well defined ?

A

Medulloblastoma

21
Q

Forms number of Homer- Wright rosettes

A

Medulloblastoma

22
Q

Highly malignant + disseminates by CSF. But it is radiosensitive

A

Medulloblastoma

23
Q

Circumscribed + Attached to the dura + has a grayish white cut surface

A

Meningioma

24
Q

Hs excellent prognosis and can be completely resected surgically?

A

Meningioma

25
Q

Psammoma bodies is seen in?

A

Meningioma

26
Q

Paraneoplastic syndromes in the CNS is most commonly associated with ?

A

small cell carcinoma of the lung

27
Q

The commonest demyelinated disease

A

MS

28
Q

Infiltration by lipid containing macrophages is seen in ?

A

MS

29
Q

Drugs that can cause Parkinsonism

A

Sodium valproate + Lithium

30
Q

Lewy bodies are seen in?

A

Parkinson’s disease

31
Q

Degenerative disease. The damage is in the ……. matter.

A

Gray matter (demyelinated = white matter)

32
Q

Accumulation of abnormal misfolded protien TDP-43 is associated with?

A

Motor neuron disease

33
Q

The commonest cause of peripheral neuropathy is?

A

GBS

34
Q

A degenerative disease of the CNS characterized by progressive dementia

A

Alzheimer’s disease

35
Q

Due to decreased acetylcholine concentrations in the nucleus basalis

A

Alzheimer’s disease

36
Q

Can also have Lewy bodies

A

Dementia

Pathology (24 decks)

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