Lipid-Lowering Agents Flashcards
When is drug therapy approrpiate for a pt with high triglycerides?
if pt cannot make dietary changes/unwilling/not working
genetic alterations
Bile Acide Sequestrants
“chole”
Cholestyramine
Colestipol
Colesevelam
What lipid lowering agents are safe for peds
Fibrates and HMG-CoA
HMG-CoA Inhibitors
“statins”
Atvorastatin
Lovastatin
Pravastatin
Rosuvastatin
Simvastatin
What is a caution for statins?
Renal impairment specifically if rhabdomyolysis occurs
What is an important herbal and food interaction for a pt to avoid with statins?
Grapefruit and St. John’s Wort
What is an important implementation for lipid-lowering agents administration?
Administer at night
Cholesterol Absorption Inhibitors
Ezetimibe
PCSK9 Inhibitors have no first pass effect because
it is a subq injection
PCSK9 inhibitors
“ocumab”
Alirocumab
Evolocumab
Fibrates
Fenofibrate
Gemfibrozil
Fenofibric Acid
Vitamin B3
Niacin
What are the indications for all lipid-lowering agents
Hypercholesterolemia
Lowers Triglycerides and LDL
Omega-3 Fatty Acids
Omega3-acid ethyl esters
Omega3-carboxylic acids
