Antifungals

Question 1

What makes fungus different than bacteria

Answer 1

rigid cell wall made of chitin
resistant to antibiotics

Question 2

Mycosis

Answer 2

fungal infection

Question 3

Who is suceptible to fungal infections

Answer 3

immunocompromised pts

Question 4

Which antifungals should be used for children?

Answer 4

fluconazole, ketoconazole, terbinafine, griseofulvin

Question 5

T or F pt should add occlusive dressing/tight diapers over areas of mycosis

Answer 5

F no tight/occlusive dressing

Question 6

T or F topical agents should be used over open or draining areas

Answer 6

F will cause systemic absorption and risk of toxicity

Question 7

T or F antifungals that have systemic effects can have hepatic dysfunction

Answer 7

T esp oral meds and in older adults

Question 8

T or F a culture is not needed for systemic antifungals to be administered

Answer 8

F cultures should always be completed prior to admin

Question 9

Azole Antifungals

Answer 9

“-conazole”
Fluconazole
Itraconazole
Ketoconazole
Voriconazole

Question 10

Indications of azoles

Answer 10

fungal infect

Question 11

action of azoles

Answer 11

binds to sterols > cell death

Question 12

Contraindications

Answer 12

allergy
hepatic/renal dys
preg/lact

Question 13

Adverse Effect

Answer 13

liver toxicity
teratogenic effects (risk vs benefit)

Question 14

Echinocandin Antifungals

Answer 14

“-fungin”
anidulafungin
caspofungin
micafungin

Question 15

Indications of echinocandin

Answer 15

funal infect

Question 16

Action of echinocandin

Answer 16

inhibit glucan synthesis

Question 17

Contraindications of echinocandin

Answer 17

allergy
heaptic/renal dys
preg/lact

Question 18

Adverse Effects

Answer 18

liver toxicity
teratogenic effects
bone marrow suppression

Question 19

Other antifungal agents

Answer 19

Amphotericin B
Griseofulvin
Nystatin

Question 20

Amphotericin B adverse effects

Answer 20

Renal toxicity
bone marrow suppression
GI effects
very toxic

Question 21

Griseofulvin indications

Answer 21

used for nail and scalp infections

Question 22

Nystatin indication

Answer 22

oral candida (thrush)

Question 23

What assessments for systemic antifungals?

Answer 23

allergy, liver/renal dys, pregnancy
CNS, skin, GI

Question 24

Nursing Conclusions for systemic antifungals

Answer 24

impaired comfort
altered sensory perception
knowledge deficit

Question 25

Implementation for systemic antifungals

Answer 25

admin entire course of drug
if IV monitor site
renal/hepatic func
give with meals, and small frequent nutritious meals for N/V/D

Question 26

Eval for systemic antifungals

Answer 26

response
effective teaching
eval comfort and safety easures
compliance

Question 27

Topical Antifungals

Answer 27

“-azole”
clotrimazole
ketoconazole
miconazole
tioconazole
Terbinafine
Tolnaftate

Question 28

Indications of Topical Antifungals

Answer 28

only for local treatment of dermatophytes, including tinea infections

Question 29

Action for Topical Antifungals

Answer 29

Prevents replication causing fungal death

Question 30

Assessment for Topical Antifungals

Answer 30

Allergies? Phys inspection for color, temperature, lesion/open areas

Question 31

Nursing Dx of Topical Antifungals

Answer 31

Impaired comfort
Impaired skin integrity risk
knowledge deficit

Question 32

Implementation of Topical Antifungals

Answer 32

Troches should be dissolved slowly in mouth

Vaginal suppositories/creams/tabs should be inserted into the vagina and lye flat for 15 min

Topical creams/lotion should be gently rubbed into area

Question 33

Adverse effects of Topical Antifungals

Answer 33

irritaiton, burning, rash, swelling at site