Antifungals Flashcards
What makes fungus different than bacteria
rigid cell wall made of chitin
resistant to antibiotics
Mycosis
fungal infection
Who is suceptible to fungal infections
immunocompromised pts
Which antifungals should be used for children?
fluconazole, ketoconazole, terbinafine, griseofulvin
T or F pt should add occlusive dressing/tight diapers over areas of mycosis
F no tight/occlusive dressing
T or F topical agents should be used over open or draining areas
F will cause systemic absorption and risk of toxicity
T or F antifungals that have systemic effects can have hepatic dysfunction
T esp oral meds and in older adults
T or F a culture is not needed for systemic antifungals to be administered
F cultures should always be completed prior to admin
Azole Antifungals
“-conazole”
Fluconazole
Itraconazole
Ketoconazole
Voriconazole
Indications of azoles
fungal infect
action of azoles
binds to sterols > cell death
Contraindications
allergy
hepatic/renal dys
preg/lact
Adverse Effect
liver toxicity
teratogenic effects (risk vs benefit)
Echinocandin Antifungals
“-fungin”
anidulafungin
caspofungin
micafungin
Indications of echinocandin
funal infect
Action of echinocandin
inhibit glucan synthesis
Contraindications of echinocandin
allergy
heaptic/renal dys
preg/lact
Adverse Effects
liver toxicity
teratogenic effects
bone marrow suppression
Other antifungal agents
Amphotericin B
Griseofulvin
Nystatin
Amphotericin B adverse effects
Renal toxicity
bone marrow suppression
GI effects
very toxic
Griseofulvin indications
used for nail and scalp infections
Nystatin indication
oral candida (thrush)
What assessments for systemic antifungals?
allergy, liver/renal dys, pregnancy
CNS, skin, GI
Nursing Conclusions for systemic antifungals
impaired comfort
altered sensory perception
knowledge deficit
