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Pharmacology > Coagulation Modifiers > Flashcards

Coagulation Modifiers Flashcards

1
Q

Antiplatelet Agents

A

aspirin
clopidogrel
ticagrelor

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2
Q

Indications for Antiplatelet Agents

A
  • prevent clogged vessels in heart and brain
    -prevent stroke/TIA
    -prevent MI
    -keep surgical graft open
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3
Q

What is a major adverse effect of antiplatelet agents

A

Bleeding

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4
Q

Anticoagulation Agents

A

Heparin
Warfarin
“-xaban”
Rivaroxaban
Apicaban
Dabigatran

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5
Q

Indications of anticoagulants

A

prevent new clot formation (a fib/bed bound/ surgery)
prevent clots from getting bigger (DVT/PE/MI)

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6
Q

What blood tests would you get for Heparin

A

PTT (60-80)

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7
Q

What blood tests would you get for Warfarin

A

INR (2-3)

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8
Q

What drugs should you NOT take with anticoagulants

A

NSAIDs/Salicylates
Antiplatelets
Thrombolytics
(anything that increases bleeding)

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9
Q

Low Molecular Weight Heparin

A

Dalteparin
Enoxaparin

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10
Q

Indication of Low Molecular Weight Heparin

A

indicated for prevention of clots/emboli after surgery/ bed rest

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11
Q

Thrombolytic Agents “Clot Busters”

A

“teplase”
Alteplase
Reteplase
Tenecteplase

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12
Q

Indication

A

acute MI
pulmonary emboli
ischemic stroke

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13
Q

What do thrombolytics do?

A

breaks down clots (plasminogen > plasmin to break down fibrin threads in clots and dissolve it)

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14
Q

Hemorrheologic Agent

A

Pentoxifylline

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15
Q

What does Pentoxifylline do?

A

Decreases platelet aggregation and decreases fibrinogen in blood
improves blood flow
used in treatment of intermittent claudication
CV stim effects

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16
Q

Antihemophilic

A

“factor”

17
Q

Indication of Antihemophilic

A

“factor” drugs are used to prevent blood loss and replace clotting factors
-bone marrow disorders
-liver disease
- hemophilia

18
Q

Adverse effects of clotting “factors”

A

it is injection so stinging, itching, burning at site
HA, flushing, fever, chills, lethargy
risks associated with use of blood products (inflammatory response)

19
Q

Hemostatic Agents

A

systemic: aminocaproic acid
topical: absorbable gelatin, collagen, fibrin, thrombin

20
Q

Indications for hemostatic agents

A

systemic: prevent clot breakdown to prevent blood loss
topical: surface injuries involving damage to small vessels in the area that clotting does not occur and blood is slowly and continually lost

21
Q

Adverse effects

A

sys: excess clotting, malaise, muscle pain, CNS,GI weak
topical: infection with sponges

Pharmacology (21 decks)

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