Lesson 2 Flashcards
Robert Hooke
- made many improvements to compound microscopes
- first to see and name “cells”
- published first comprehensive book of microscopy (Micrographia)
Cell Theory
- cells are the building blocks of all plants and animals
- all cells come from the division of pre-existing cells
- cells are the smallest unit that perform all vital physiological functions
- each cell maintains homeostasis at the cellular level
why is cell size limited?
surface area to volume ratios
somatic cells
body cells, formed by mitosis
sex cells
germ cells, reproductive cells
ECF
extracellular fluid, includes any fluid outside the cells
- interstitial fluid, blood plasma, lymph, cerebrospinal fluid, etc.
cytoplasm
region between the plasma membrane and nucleus
cytosol
the clear gel/intercellular fluid within the cytoplasm
functions of the plasma membrane (4)
- physical barrier
- regulates entry/exit of material into/out of cells
- responses to changes in the ECF
- provides support to the cell
phospholipids
- 75% of membrane lipids
- amphipathic arrange in a bilayer
- drift laterally, keeping membrane fluid
cholesterol
holds phospholipids still and can stiffen membranes
glycolipids
phospholipids with short carbohydrate chains on extracellular face; contribute to glycocalyx
glycocalyx
carbohydrate component of glycoproteins and glycolipids located external to plasma membrane
- unique in everyone but identical twins
functions of the glycocalyx (7)
- protection
- immunity to infection
- defense against cancer
- transplant compatibility
- cell adhesion
- fertilization
- embryonic development
transmembrane proteins
pass completely through the membrane
most are glycoproteins
peripheral proteins
adhere to one face of the membrane
functions of membrane proteins
receptors, enzymes, channel proteins, carrier, cell-identity markers, cell-adhesion molecules (CAMs)
functions of membrane proteins: receptors
bind chemical signals to trigger internal changes, may cause production of a second messenger
functions of membrane proteins: enzymes
catalyze reactions including digestion of molecules, production of second messengers
functions of membrane proteins: channel proteins
allow hydrophilic solutes and water to pass through the membrane
leak channels
channel proteins that are always open
gate channels
channel proteins that open only when triggered
ligand-gated channels
channel proteins that respond to chemical messengers
voltage-gated channels
channel proteins that respond to charge changes
mechanically gated channels
channel proteins that respond to physical stress on cells
functions of membrane proteins: carriers
bind solutes and transfer them across the membrane
pumps
carriers that consume ATP to move substances across the membrane against its concentration gradient
functions of membrane proteins: cell-identity markers
glycoproteins act as identification tags
functions of membrane proteins: cell-adhesion
mechanically link cells to other cells and to extracellular material
osmotic pressure
hydrostatic pressure required to stop osmossis
hydrostatic pressure
fluid pressure on the membrane
reverse osmosis
process of applying mechanical pressure to override osmotic pressure
osmolarity
osmotic concentration; quantity of non-permeating solutes per liter of solution
tonicity
ability of a surrounding solution to affect fluid volume and pressure in a cell
carrier-mediated transport
proteins in a cell membrane carry solutes into/out of the cell
carriers exhibit two main characteristics
specificity and saturation
uniport
carrier that moves one type of solute
ex. calcium pump
symport
carrier that moves two or more solutes simultaneously in the same direction, aka cotransport
anitport
carrier that moves two or more solutes in opposite directions, aka countertransport
vesicular transport
moves large particles, fluid droplets, or numerous molecules at once through the membrane in vesicles
phagocytosis
engulfing and destroying large particles, aka cell eating
pinocytosis
taking in droplets of ECF containing molecules useful in the cells, aka cell drinking
receptor-mediated endocytosis
particles bind to specific receptors on plasma membrane