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RUSVM Virology Summer 2017 > Lecture Questions (from exam 1) > Flashcards

Lecture Questions (from exam 1) Flashcards

1
Q

Which one of the following is not a component of a virus?

a. Nucleic Acid
b. Capsid
c. Envelope
d. Capsule

A

d. Capsule

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2
Q

The viral matrix protein is located between the viral nucleic acid (DNA/RNA) and the capsid

a. True
b. False

A

b. False

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3
Q

Which one of the following is not a mechanism of genetic diversity of viruses?

a. Reassortment
b. Point Mutations
c. Recombination
d. Conjugation

A

d. Conjugation

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4
Q

Nonstructural proteins are seen in extracellular virions

a. True
b. False

A

b. False

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5
Q

An incomplete virion is composed of

a. Only nucleic acid (DNA/RNA)
b. Only lipid envelope
c. Only capsid
d. Lipid envelope and nucleic acid, no capsid

A

c. Only capsid

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6
Q

The family of a virus is denoted by suffix

a. Virales
b. Viviane
c. Virus
d. Viridae

A

d. Viridae

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7
Q

What would you use to detach and dissociate cells for subculture?

a. Tyrosine
b. Renin
c. Trypsin
d. Pepsin

A

c. Trypsin

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8
Q

In rate zonal centrifugation, virus particles are separated on basis of their buoyant density

a. True
b. False

A

b. False

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9
Q

Which of the following is not a physical assay for quantification of viruses?

a. Electron Microscopy
b. ELISA
c. Pock Assay
d. qPCR

A

c. Pock Assay

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10
Q

A PFU/mL of 300 means
a. 300 viruses are present in 1 mL of sample to cause one plaque in monolayer cell culture
b. One virus is present per mL of sample to form 300 plaques in monolayer cell culture
c. The minimum # of viruses present per mL of the sample to form 300 plaques in monolayer cell
culture

A

c. The minimum # of viruses present per mL of the sample to form 300 plaques in monolayer cell
culture

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11
Q

Viruses can enter the host cell using any receptor present on the surface of the host cell

a. True
b. False

A

b. False

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12
Q

Which one of the following methods cannot be used by viruses for penetrating into the host cell?

a. Receptor-mediated endocytosis
b. Membrane Fusion
c. Pore-mediated penetration
d. Exocytosis

A

d. Exocytosis

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13
Q

The Poly-A tail is added to the 3’- end of viral mRNA

a. True
b. False

A

a. True

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14
Q

Viruses can acquire the lipid envelope only from the cell membrane of infected host cells

a. True
b. False

A

b. False

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15
Q

Virus A has an LD50 of 30. Virus B has an LD50 of 50. Which is more virulent?

a. Virus A
b. Virus B

A

a. Virus A

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16
Q

Mosquito bites can transmit some viruses directly to the blood. This is a case of active viremia

a. True
b. False

A

b. False

17
Q

Viruses can enter the CNS from blood by…

a. Monocyte trafficking
b. Breaking the cementing at endothelial junctions
c. Increase permeability of endothelium
d. All of the above

A

d. All of the above

18
Q

A family of viruses may prefer a particular organ for effective replication. The term used to describe this is

a. Affinity
b. Pathogenicity
c. Tropism
d. Virulence

A

c. Tropism

19
Q

Which one of the following is not usually a feature of persistent viral infection?

a. Virus may remain dormant in host cell
b. Reactivation (clinical disease) occurs during stress
c. Intermittent shedding of virus for long periods
d. Rapid clearance from host immune response

A

d. Rapid clearance from host immune response

20
Q 
In Tissue Culture, visible morphological changes / damages to monolayer cells resulting from virus
infection is also known as
a. Teratogenic Effect
b. Cytopathic Effect
c. Lethal Effect
d. Somatopathic Effect
A

b. Cytopathic Effect

21
Q

Apoptosis is a ‘sort of’ host defense mechanism against viral infection

a. True
b. False

A

a. True

22
Q

Which of the following is a tumor suppressor gene/protein?

a. CDK
b. E2F
c. Rb
d. None of the above

A

c. Rb

23
Q

Replication of Oncogenic DNA viruses in a permissive host cell usually causes host-cell transformation and cancer

a. True
b. False

A

b. False

24
Q

Interferons are virus specific, i.e. for each virus there will be a specific interferon

a. True
b. False

A

b. False

25
Q

Adaptive Immunity is virus specific

a. True
b. False

A

a. True

26
Q

Rapid changes in the structure of viral antigen of a virus over time due to mutations is also known as
Antigen Multiplicity
a. True
b. False

A

b. False

27
Q

Rabies has never been reported before in St. Kitts. Suddenly, a few cases of canine rabies are reported
from St. Kitts, especially among dogs that accompanied incoming RUSVM students from the USA. In this context, rabies would be ______ disease in St. Kitts
a. Enzootic
b. Panzootic
c. Exotic
d. Epizootic

A

c. Exotic

28
Q

Hospital Acquired Infection is also known as Nosocomial Transmission

a. True
b. False

A

a. True

29
Q

Enteric Viruses have been shown to be more stable in environment than Respiratory viruses

a. True
b. False

A

a. True

30
Q

What would be a good time frame to collect samples for virus isolation

a. Within 3 days of appearance of clinical signs
b. Within 7 days of appearance of clinical signs
c. Within 14 days of appearance of clinical signs
d. Within a month of appearance of clinical signs

A

a. Within 3 days of appearance of clinical signs

31
Q

A Transmission Electron Microscope (TEM) yields 3D images

a. True
b. False

A

b. False

32
Q 
Vacutainer tubes used to collect blood sample to obtain serum for diagnostic purposes usually have
\_\_\_\_ colored caps
a. Lavender
b. Blue
c. Red
d. Orange
A

c. Red

33
Q

POCs in viral diagnostics is the abbreviation for?

a. Patient on Care Assays
b. Point of Care Assays
c. Point of Control Assays
d. Positive on Control Assays

A

b. Point of Care Assays

RUSVM Virology Summer 2017 (23 decks)

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