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RUSVM Virology Summer 2017 > Family: Adenoviridae > Flashcards

Family: Adenoviridae Flashcards

1
Q

Adenoviridae are _________, precisely _______, and have ____ vertex _______ capsomeres each with a fiber protruding from the surface of capsid.
A. Enveloped, hexagonal, 12, penton
B. Non-enveloped, pentagonal, 12, hexagon
C. Non-enveloped, hexagonal, 12, penton
D. Enveloped, pentagonal, 12, hexagon

A

C. Non-enveloped, hexagonal, 12, penton

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2
Q 
Adenoviridae have what type of inclusion bodies?
A. Intranuclear
B. Intracytoplasmic
C. Borrel
D. Bollinger
A

A. Intranuclear

–and they contain large numbers of virions, often in a para-crystalline array

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3
Q

Which of the following is not a general property of Adenoviridae?
A. many adenoviruses have agglutinate red blood cells. Hemagglutination occurs when the tips of pentane fibers bind to surface receptors on RBCs
B. Some viruses are oncogenic in lab animals
C. They are relatively stable in the environment and are not easily inactivated by disinfectants
D. Most have narrow host ranges.

A

C. They are relatively stable in the environment and are not easily inactivated by disinfectants
– They ARE easily inactivated by disinfectant!!

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4
Q

Which of the following is/are pathogenesis of adenoviruses?
A. many cause acute respiratory or gastroenteric disease, which is mostly subclinical
B. Immunosuppression
C. Long periods of latency
D. Oncogenesis
E. All of the above

A

E. All of the above
–Long periods of latency: persist in lymphoid and other tissues; is reactivated in immunocompromised animals; and can be highly pathogenic in immunodeficient animals.

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5
Q

Which of the following is true about the genus Mastadenovirus?
A. Avian adenoviruses
B. Mammalian adenoviruses
C. A single pentane fiber projects from each vertex
D. Each penton fiber is bifurcated, appear as two fibers extending form each penton base
E. A and C
F. A and D
G. B and C
H. B and D

A

G. B and C

–Mammalian adenoviruses; A single pentane fiber projects from each vertex

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6
Q

Which of the following is true about the genus Aviadenovirus?
A. Avian adenoviruses
B. Mammalian adenoviruses
C. A single pentane fiber projects from each vertex
D. Each penton fiber is bifurcated, appear as two fibers extending form each penton base
E. A and C
F. A and D
G. B and C
H. B and D

A

F. A and D

–Avian adenoviruses; Each penton fiber is bifurcated, appear as two fibers extending form each penton base

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7
Q 
Which of the following are in genus mastadenovirus?  
A. Canine Adenovirus-1
B. Canine Adenovirus-2
C. Equine Adenovirus-1 
D. Equine Adenovirus-2
E. A, B and C
F. All of the above
A

F. All of the above

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8
Q 
Which f the following does Canine adenovirus- 1 cause? 
A. Infectious Canine Hepatitis
B. Canine Distemper 
C. Rubarth's Disease
D. Kennel cough
E. A and B 
F. A and C
G. A, B and C
A

F. A and C

  • -Infectious Canine Hepatitis. Also known as Rebirth’s Disease
  • -Canine distemper is Paramyxoviridae –don’t need to know this
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9
Q

T/F: Acute infection of Canine adenovirus- 1 is found in all secretions and excretions. Afterward, virus shed in urine for last least 6 to 9 months.

A

True!

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10
Q 
What is the route of transmission for CAV-1? 
A. Fecal- oral
B. Oronasal
C. Skin cut
D. all of the above
A

B. Oronasal

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11
Q

All of the following are ways in which dogs can get infectious canine hepatitis, except:
A. Secretions/ excretions contact from an infected dog
B. Contaminated fomites
C. Ectoparasites that harbor CAV-1
D. Endoparasites that harbor CAV-1

A

D. Endoparasites that harbor CAV-1

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12
Q 
Which of the following is NOT a main target organ for CAV-1?
A. Liver
B. Kidney
C. Heart
D. Lungs
E. Spleen
A

C. Heart

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13
Q 
Which of the following is not a pathogenesis of infectious canine hepatitis? 
A. Hepatitis
B. Kidney
C. Pneumonia
D. Ocular lesions
A

C. Pneumonia

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14
Q

T/F: Acute infection of the kidney due to CAV-1 results in Glomerulonephritis.

A

True!

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15
Q

T/F: Chronic kidney lesions may result form immune- complex reactions after recovery from acute or subclinical disease and will cause chronic glomerulonephritis.

A

True!

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16
Q

T/F: Hepatitis caused by Canine infectious hepatitis shows an antibody titer of >500 at time of infection, >500 antibody response by day 7 post infection (clears virus form blood and liver and restricts hepatic damage). A persistently low antibody titer (<4) will lead to widespread hepatic necrosis. Partial immunity (titer >16 but <500) may result in chronic active hepatitis and hepatic fibrosis.

A

True!

17
Q 
When can ocular lesions be seen in dogs that have Canine adenovirus-1? 
A. before recovery 
B. Acute cases
C. Chronic cases
D. during recovery
E. After recovery 
F. A and C
G. B and C
H. C and D
I. C and E
A

H. C and D

–Chronic cases during recovery

18
Q

Put the following in order of how corneal edema develops in CAV-1:
1) Disruption of intact corneal endothelium allows aqueous to enter the cornea
2) CAV-1 antibody production increases, and formation of viral- antibody immune complexes
3) Cause extensive damage to corneal endothelium
4) Accumulation of edematous fluid within corneal storms results in corneal edema
5) This results in complement activation and neutrophil Chemotaxis
A. 2, 5, 3, 1, 4
B. 3, 2, 1, 5, 4
C. 5, 1, 2 ,4, 3
D. 4, 1, 3, 5, 2

A

A. 2, 5, 3, 1, 4

19
Q

What complication(s) can occur due to Infectious canine hepatitis?
A. Bacterial Pyelonephritis resulting from renal damage
B. DIC
C. Pneumonia
D. A and B
E. all of the above

A

D. A and B

20
Q

Which of the following is not true in regards to clinical signs of canine infectious hepatitis?
A. Most frequent in dogs less than 1 year old of age
B. Concurrent parvoviral or distemper infection worsens the prognosis
C. Unvaccinated dogs of only young ages are susceptible
D. Most infections are asymptomatic
E. Signs vary form a slight fever to death

A

C. Unvaccinated dogs of only young ages are susceptible

–Unvaccinated dogs of ALL ages are susceptible

21
Q 
Severely infected dogs become moribund and die within a few hours after onset of clinical signs in this form of CAV-1. 
A. Peracute 
B. Acute
C. Subacute
D. Chronic
A

A. Peracute

22
Q 
Which form of CAV-1 gives fevers of over 104 degrees C; vomiting; petechiae hemorrhages; Jaundice; Enlarged tonsils and lymph nodes;  Edema of hand, neck and trunk; Convulsions from forebrain damage as a result of vascular injury; Icterus; And Corneal Edema and anterior uveitis when clinical recovery begins? 
A. Peracute 
B. Acute
C. Subacute
D. Chronic
A

B. Acute

23
Q 
Which of the following is/ are appropriate method(s) to diagnose Canine Adenovirus-1? 
A. Clinical signs
B. Necropsy and histopathology 
C. Biochemistry and Hematology
D. Virus Isolation from Urine
E. All of the above
A

E. All of the above

24
Q

T/F: Treatment of Infectious Canine Hepatitis is symptomatic and supportive. The goal of therapy are to limit secondary bacterial invasion, support fluid balance and control hemorrhagic tendencies.

A

True!

–KNOW THIS HE SAID IT WAS VERY IMPORTANT!

25
Q

Which of the following is not a form of immunity to infectious canine hepatitis?
A. Recovered animals are immune to systemic form of disease
B. Maternal antibodies interferes with active immunization until puppies are 9 to 12 weeks of age
C. Attenuated CAV-1 Vaccines have produced transient unilateral or bilateral opacities of the cornea. Vaccine virus can cause mild subclinical interstitial nephritis, and may be shed in urine.
D. Attenuated CAV-2 Live Virus Strains provide cross-protection against CAV-1. CAV-2 attenuated vaccines are preferentially used because they have very little tendency to produce corneal opacities or uveitis, and the virus is not shed in urine
E. all of the above are forms of immunity

A

E. all of the above are forms of immunity

26
Q

Which virus has been Discontinued for the use of Canine Adenovirus 1 control?/
A. Attenuated CAV-2 live virus strains
B. Attenuated CAV-1 live vaccine
C. Non- Attenuated CAV-2 live virus strains
D. Non-Attenuated CAV-1 live vaccine

A

B. Attenuated CAV-1 live vaccine

27
Q 
Which of the following causes Kennel cough in dogs/ Canine Infectious Tracheobronchitis? 
A. CAV-1
B. CAV-2
C. Bordetella bronchiseptica 
D. Both A and C
E. Both B and C
F. All of the above
A

E. Both B and C

–CAV-2 and Bordetella bronchiseptica

28
Q 
Which of the following is not correct regarding the transmission of Kennel cough? 
A. It is Highly contagious 
B. Via aerosolized droplens
C. Stress increases severity of disease
D. Vector transmits it
A

D. Vector transmits it

29
Q

T/F: Uncomplicated canine infectious tracheobronchitis can present as a hard, dry cough followed by gagging. It can also cause rhinitis, sous nasal discharges, and sometimes conjunctivitis.

A

True!

30
Q

T/F: complicated forms of infectious tracheobronchitis can present as sever pneumonia or bronchopneumonia and can be life threatening.

A

True!

31
Q 
When can Antitussives (cough suppressants) be used to treat Kennel cough? When combined with...
A. bronchoconstrictors 
B. bronchodialators 
C. vasoconstrictors
D. vasodilators
A

B. bronchodialators

32
Q

T/F: Immunity of kennel cough can be gained through modified- live vaccines against distemper, parainfluenza, and CAV-2, which also provides proaction against CAV-1.

A

True!

33
Q

Which of the following is incorrect in regards to Equine Adenovirus?
A. Equine Adenovirus (EAV-1) and Equine Adenovirus-2 (EAV-2) are involved
B. Most equine adenovirus infections are asymptomatic or present as mild upper or lower respiratory tract disease
C. EAV-2 is associated with severe respiratory disease in Severe Combined Immunodeficiency (SCID) foals
D. As maternal antibody wanes, these foals become susceptible to adenovirus infection. Infection is progressive and these foals invariably die within 3 months of age

A

C. EAV-2 is associated with severe respiratory disease in Severe Combined Immunodeficiency (SCID) foals
–Should be EAV-1 not EAV-2!! –> EAV-1 is associated with severe respiratory disease in Severe Combined Immunodeficiency (SCID) foals

34
Q

T/F: Foals with SCID can present with severe bronchiolitis and pneumonia. Respiratory distress and other related signs.

A

True!

35
Q 
Which animal species can be infected with an aviadenovirus infection causing Inclusion Body hepatitis or Egg Drop Syndrome '76? 
A. Turkeys
B. Ducks
C. Chickens
D. Pheasants 
E. Quail
A

C. Chickens

–KNOW THIS HE SAID IT WAS VERY IMPORTANT!

36
Q 
Which animal species can be infected with an aviadenovirus infection causing Hepatitis (rare)?
A. Turkeys
B. Ducks
C. Chickens
D. Pheasants 
E. Quail
A

B. Ducks

–KNOW THIS HE SAID IT WAS VERY IMPORTANT!

37
Q 
Which animal species can be infected with an aviadenovirus infection causing Bronchitis?
A. Turkeys
B. Ducks
C. Chickens
D. Pheasants 
E. Quail
A

E. Quail

–KNOW THIS HE SAID IT WAS VERY IMPORTANT!

38
Q 
Which animal species can be infected with an aviadenovirus infection causing Hemorrhagic Enteritis and Egg Drop Syndrome? 
A. Turkeys
B. Ducks
C. Chickens
D. Pheasants 
E. Quail
A

A. Turkeys

–KNOW THIS HE SAID IT WAS VERY IMPORTANT!

39
Q 
Which animal species can be infected with an aviadenovirus infection causing Marble Spleen Disease?
A. Turkeys
B. Ducks
C. Chickens
D. Pheasants 
E. Quail
A

D. Pheasants

–KNOW THIS HE SAID IT WAS VERY IMPORTANT!

RUSVM Virology Summer 2017 (23 decks)

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