Lecture 8: Pulm and Ophthalmology Flashcards
What is the leading cause of infant hospitalization?
Bronchiolitis
Overview of Bronchiolitis
- Clinical syndrome of resp distress < 2 yo
- Lower respiratory tract infection
- Causes URI symptoms, followed by acute onset of wheezing, crackles, hyperinflation, and tachypnea.
MCC of bronchiolitis
RSV (50-95% of cases)
What age do most cases of bronchiolitis occur during?
1st year of life, esp 1-10mo old.
80% of cases are 1st year.
RFs for HIGH RISK bronchiolitis
- PREEMIE
- Age < 12 wks
- Cardiopulm disorders
Guidelines for high risk are different than regular!
If an infant has had multiple instances of wheezing, how do we approach in terms of bronchiolitis tx?
Do not follow bronchiolitis guidelines for a recurrent wheezer.
Bronchiolitis is primarily referring to the initial episode.
Dx of bronchiolitis
- Clinical
- O2 sat
- NP swab
- No imaging necessary
NP swab is really only for pts getting admitted.
Tx of nonsevere bronchiolitis
- Supportive care
- Hydration
- Relieving nasal congestion
- Monitor for worsening
It is viral.
Indications for hospitalizing bronchiolitis
- Increasing respiratory effort
- Hypoxemia < 92% (disclaimer: might drop when sleeping, thats ok)
- Apnea
- Acute resp failre
- Toxic looking
- Poor feeding
- Lethargy
- Dehydration
- Parents can’t care for child at home (social concerns)
Assess them WITHOUT a fever! Fever will change presentation.
Inpatient management of bronchiolitis
- Hydration
- Nasal suctioning
- Supplemental O2 between 90-92%
- CPAP if risk of resp failure
- ETT last resort
If they are febrile, control fever and reassess after its controlled.
When is an antiviral used in bronchiolitis and which one?
Ribavirin can be used for significant immunocompromised pts only
Discharge criteria for bronchiolitis
- RR < 60 for < 6mo old
- Stable on RA
- Caretaker knows how to bulb suction
- Adequate PO intake
- Caretakers can take care at home
- Resources at home are sufficient
What is to be AVOIDED in bronchiolitis?
- Inhaled BDs
- Systemic glucocorticoids
- Inhaled saline
Pt education pearls for bronchiolitis
- Improvement within a few days
- Discharge takes 3-7 days
- Cough/congestion takes 1-2 weeks to resolve.
Prevention of bronchiolitis
- Palivizumab (Beginning of RSV and monthly throughout RSV season)
- Nirsevimab (single shot and cheaper!)
Do not need to memorize recommendations!!
Can you coadminister the MABs for bronchiolitis with other childhood vaccines?
Yes
Overview of CF
- Autosomal recessive inheritance
- MC Lethal genetic disease
- Develops bronchiectasis and thick mucus over time.
- MC in caucasians
Where is the mutation for CF?
Chromosome 7, defect in CF gene that regulates CFTR channels
Essentially an inability to clear mucus properly.
CF transmembrane conductance regular protein
How do we dx CF?
- Newborn screening
- Meconium ileus
- Respiratory symptoms
- Failure to thrive
Delay in passing meconium
What part of the newborn screen checks for CF?
Heelstick
What sign is virtually diagnostic of CF until a confirmatory test is performed?
Meconium Ileus = CF until we do a sweat test or genotyping/
What is the primary underlying cause for failure to thrive in a CF pt?
Pancreatic failure of the acini cells (digestive), overall leading to malabsorption
Pancreatic insufficiency + malabsorption + recurrent pancreatitis
Gold standard test to Dx CF
Sweat chloride test, showing > 60 mmol/L for a positive test, and 40-60 as borderline/retest!
Normal is < 30 mmol/L
When is genotyping done for CF?
- After sweat chloride is positive
- Checking carrier status or borderline sweat chlorides
How do we check for pancreatic insufficiency in CF patients?
Fecal elastase, which is absent in most CF pts.
Tx of CF pts
- Peds
- Peds pulm
- RT
- Diet/Nutriton
- Social Work