Cong infections trigger Flashcards
protozoan
toxoplasmosis
screen moms with cervical LAD and high fever.
what would the screening show?
toxoplasmosis
US showing clacifications or cerebral ventricular dilation are MC
cat feces and raw meat
toxoplasmosis
s/s include hydrocephalus, microcephaly, anemia, and chorioretinitis
toxoplasmosis:
Cataracts/chorioretinitis
Calcifications in brain
Hearing loss
Hydrocephalus
Anemia
Seizures
Microcephaly
s/s shows seizures, hearing loss, cataracts and calcifications of the brain
toxoplasmosis
Cataracts/chorioretinitis
Calcifications in brain
Hearing loss
Hydrocephalus
Anemia
Seizures
Microcephaly
focal necrotizing retinitis
toxoplasmosis
dx with ELISA and CXR that shows diffuse cortical calcifications
toxoplasmosis
tx with spiramycin if <14 weeks gestation.
what about after 14 weeks?
toxoplasmosis
> 14wks gestation = pyrimethamine + Sulfadiazine + folic acid
eye exam every 3 months for 18 months + pharmacological tx
toxoplamosis postnatal tx.
also Pyrimethamine + sulfadiazine + folinic acid for 1 yr
PDA and pulm artery stenosis, hearing loss, mental retardation, microcephaly and cataracts
what symptom are we missing?
rubella
blueberry muffin syndrome
low platelet count (thrombocytopenia)
rubella (petechiae and purpura)
can also be seen in CMV!
infants with this disease are chronically infected for a whole year and shed the virus into their stool, urine and respiratory secretions
rubella
Doublestranded DNA Herpes Virus
CMV
transmissible through saliva, blood and breastmilk
CMV
MC congenital infection
CMV
leading cause of NON hereditary sensorineural hearing loss
CMV
elevates LFTs, thrombocytopenia, elevated bilirubin
CMV
dx with urine/saliva test and a CT scan which will show periventricular lesions
CMV
not treated unless there is SEVERE sickness and you recieve approval from the FDA
CMV
ganciclovir and valganciclovir.
in a baby who is septic with fever and irritability but a negative bacteriologic culture, what should we suspect?
disseminated HSV infection
will have abnormal CSF and possible liver dysfunction
scarring eye damage, skin lesions, ulcerations
HSV