Lecture 8 Flashcards
Where does pox virus assemble
In cytoplasm
Are poxviruses zoonotic
yes, in some domestic animals they can be
What doe all poxviruses cause
Skin lesions
Infection with what prevents smallpox
Cow pox
What does the viral core of poxvirus contain
RNA polymerase
What happens to viral proteins in pox virus before DNA replication
They are translated
Where are viral particles constructed in poxvirus
In cytoplasm within viral factories
In poxvirus, where is DNA replication occurring
In the cytoplasm
How is DNA replicated in poxvirus
as long concatemers
How can pox virus infect their host (3)
- Though skin by mechanical means
- Respiratory tract
- Oral route
What can poxvirus pathogenesis be (2)
- Localised
2. Systemic
Where does initial replication of poxvirus occur
At site of infection
How is poxvirus taken from lymph nodes to blood
via thoracic duct
What do Poxviruses target
Primary immune mediators
What form is poxvirus usually in
Cutaneous form
What form is poxvirus usually in canarys
Systemic form
In canaries what does the systemic disease present (2)
- Hepatic necrosis
2. Pulmonary nodules
What is the genus of fowlpox
Avipoxvirus
Occurrence of poxvirus
Worldwide
What are the 2 forms of fowlpox
- Cutaneous form
2. Diphtheroid form
What does the cutaneous form of fowlpox cause
Nodular lesions on the comb, wattle, eyelids, other non feathered areas
What does the diphtheroid form of fowlpox cause
Nodules on mucosal membranes of pharynx, trachea, oesophagus
How to diagnose fowlpox (4)
- Skin lesions
- Tracheal lesions
- Histopathology
- PCR
How to control fowlpox
- Cell culture propagated vaccine can be used on day old chicks
- Avain embryo origin injection
