Lecture 8 Flashcards
Where does pox virus assemble
In cytoplasm
Are poxviruses zoonotic
yes, in some domestic animals they can be
What doe all poxviruses cause
Skin lesions
Infection with what prevents smallpox
Cow pox
What does the viral core of poxvirus contain
RNA polymerase
What happens to viral proteins in pox virus before DNA replication
They are translated
Where are viral particles constructed in poxvirus
In cytoplasm within viral factories
In poxvirus, where is DNA replication occurring
In the cytoplasm
How is DNA replicated in poxvirus
as long concatemers
How can pox virus infect their host (3)
- Though skin by mechanical means
- Respiratory tract
- Oral route
What can poxvirus pathogenesis be (2)
- Localised
2. Systemic
Where does initial replication of poxvirus occur
At site of infection
How is poxvirus taken from lymph nodes to blood
via thoracic duct
What do Poxviruses target
Primary immune mediators
What form is poxvirus usually in
Cutaneous form
What form is poxvirus usually in canarys
Systemic form
In canaries what does the systemic disease present (2)
- Hepatic necrosis
2. Pulmonary nodules
What is the genus of fowlpox
Avipoxvirus
Occurrence of poxvirus
Worldwide
What are the 2 forms of fowlpox
- Cutaneous form
2. Diphtheroid form
What does the cutaneous form of fowlpox cause
Nodular lesions on the comb, wattle, eyelids, other non feathered areas
What does the diphtheroid form of fowlpox cause
Nodules on mucosal membranes of pharynx, trachea, oesophagus
How to diagnose fowlpox (4)
- Skin lesions
- Tracheal lesions
- Histopathology
- PCR
How to control fowlpox
- Cell culture propagated vaccine can be used on day old chicks
- Avain embryo origin injection
Where do lesions of caripoxvirus develop
Lungs and respiratory tract
What type of disease are capripoxvirus know as
Transboundary disease
How many serotypes exist of sheeppox and goatpox
1
What economic importance do pox viruses have
- Can be fatal
2. Limit trade and export
What does leporipoxvirus cause
Benign fibromas
What happens to rabbits that survive leporipoxvirus (Myxoma virus)
Subcutaneous gelatinous swellings appeal all over the body
How can parapoxvirus be distinguished morphologically
Narrower and have a more oval shape
How long can the Orf virus live
Years
Is the Orf virus zoonotic
Yes
How to prevent parapoxvirus (2)
- Vaccinate
2. Disinfect equipment
How long does it take to gain immunity with parapoxvirus after being vaccinated
2 weeks
What does bovine parapoxvirus cause
Mild lesions on muzzle
Where do adenoviridae viruses replicate
Nucleus
What sort of infections are associated with adenoviruses
- Respiratory
- Eye
- GIT
What does CAV-1 replicate
Vascular endothelial cels as well is a hepatic and renal parenchyma cells
What are the majority of infections of CAV-1
Asymtomatic
What is CAV-2 responsible for
Respiratory disease
What diagnosis technique is used to identify the serology of CAV-1/2 (2)
- ELSIA
2. HAI
How can you control CAV-1/2
Vaccine
Hoe are FAdVs transmitted
Horizontally as well as vertically
How do you control IBH in broilers
Vaccinating breeding birds
How are broilers protected from IBH
they have maternal antibodies
