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Virology > Lecture 16 > Flashcards

Lecture 16 Flashcards

1
Q

What are the subfamilies of Herpesviridae (3)

A
  1. Alphaherpesvirinae
  2. Betaherpervirinae
  3. Gammahepesvirinae
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2
Q

Where is Equid alphaherpesvirus 1 and 4

A

In horses

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3
Q

What does EHV-1 cause

A

respiratory disease, abortion and neurologic disease

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4
Q

What does EHV-4 cause

A

Respiratory disease

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5
Q

Where is EHV-1 and -4 most commonly seen

A

Weaned foals and yearlings

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6
Q

Clinical signs of EHV-1 and -4

A

Coughing, nasal discharge, enlargement of the mandibular and/or retropharyngeal lymph nodes, lethargy, anorexia, conjunctivitis

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7
Q

Clinical signs of EHM (5)

A
  1. Incoordination of hind
  2. Ataxia
  3. Urine retention
  4. Recumbency
  5. Neurological sigs are preceded by fever and/or respiration
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8
Q

How to diagnose EHV-1 and -4 (3)

A
  1. Laboratory diagnosis with histological lesions
  2. Viral antigens
  3. Viral genome can be detected using specific PCR
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9
Q

What are the vaccines of EHV-1 and EHV-4 (2)

A
  1. Live attenuated and inactivated vaccines

2. Reduce abortion and CNS infection

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10
Q

Equid gammeherpesvirus 2 and 5 is present where?

A

Horses

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11
Q

What is associated with Equine Multinodular Pulmonary Fibrosis

A

EHV-5 and with EHV-2, can be linked with a characteristic interstitial lung fibrosis

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12
Q

What does Equine Multinodular Pulmonary Fibrosis affect

A

Older horses causing weightless and reduced ability to exercise as result of the formations of nodular lesions in the lungs

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13
Q

Where does Equid alphaherpesvirus cause lesions

A

Penis and vulva

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14
Q

What are the clinical signs of canid alphaherpesvirus 1 in pups

A

Generalised necrotising and haemorrhage disease

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15
Q

How can pups become infected with canid alphaherpesvirus

A

Neonatal, this causes vocalisation, anorexia, dyspnoea, abdominal pain, incoordination and soft faeces

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16
Q

What is felid alphaherpesvirus

A

Upper respiratory tract disease

17
Q

What are the clinical signs of felid alphaherpesvirus

A

Coughing, sneezing, nasal discharge, conjunctivitis and sometimes fever and loss of appetite

18
Q

What is gallid alphaherpesvirus

A

Infectious laryngotracheitis

19
Q

What does gallid alphaherpesvirus

A

Conjunctivitis, pharyngitis and tracheitis

20
Q

What are early signs of gallid alphaherpesvirus

A

Hard swallowing, ruffled feathers on back of head, squinting and conjunctivitis

21
Q

What are the classic signs of gallid alphaherpesvirus

A

Coughing, gasping and expending the neck forward and upward with each breath to clear mucous from trachea

22
Q

How is ILT transmitted from animal to animal

A

Respiratory secretions

23
Q

How can ILT be transmitted between flocks

A

aerosols or fomites

24
Q

What is gallid alphaherpesvirus 2 also known as

A

Marek’s Disease

25
Q

What are the clinical signs of Marek’s disease

A

Depression, paralysis, appetite loss, weight loss, anaemia, dehydration

26
Q

What are the Marek’s disease vaccine derived from

A
  1. Attenuated versions of the wild type virus (serotype 1)
  2. A related Marek’s disease virus (serotype 2)
  3. A related herpesvirus from turkeys (serotype 3)
27
Q

What are the first signs of Anatid alphaherpesvirus 1 in flocks

A

High persistent mortality with significant drop in egg production in laying flocks

28
Q

What is Suid alphaherpesvirus also known as

A

Aujeszky’s disease

29
Q

How is Aujeszky’s disease spread

A

Nose-to-nose contact between pigs

30
Q

How to diagnose Aujeszky’s disease

A

Detection of antigen or viral DNA in tissue

31
Q

What is Bovine alphaherpesvirus also known as

A

Infectious bovine rhinotracheitis

32
Q

How can viral DNA of Bovine alphaherpesvirus be detected

A

PCR

33
Q

What does Bovine alphaherpesvirus 5 cause

A

Meningoencephalitis and mild respiratory disease in cattle

34
Q

What are the 2 Bovine alphaherpesvirus 2 caused in cattle

A
  1. Bovine mammillitis - often associated with early winter and first lactation heifers
  2. Pseudo-lumpy skin disease - characterised by a generalised eruption of superficial cutaneous nodules
35
Q

What does Malignant catarrhal fever infect

A

Cattle

36
Q

What are the clinical signs of Malignant catarrhal fever (4)

A
  1. Fever, depression, weakness, diarrhoea
  2. Muzzle and nares are encrusted
  3. Bilateral keratitis
  4. Ataxia, nystagmus and head pressing
37
Q

Where do Herpesviruses replicate

A

Nucleus

Virology (23 decks)

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