lecture 7 antibacterial drugs Flashcards
antimicrobial
a natural or synthetic chemical that kills or inhibits the growth of microorganisms
ideal antibacterial properties
no resistance
narrow spectrum of activity
bactericidal
selective
what do beta lactam antibiotics target
peptidoglycan
what can work on the cell wall of gram pos
glycopeptides
why cant glycopeptides work on gram neg
cell wall is too thick
eukaryotic ribosomes
80s
bacteria ribosomes
70s
examples of 30s inhibitors
aminoglycosides
tetracylines
aminoglycans are bacterio-
bactericidal
tetracylcines are bacterio
bacteriostatic
common feature of amnioglycans and tetracyclines
both can be taken up by eaukaryotes
what inhibits DNA synthesis
quinalones
quinalone administration
oral
what do rifamycins do
block mRNA synthesis
sulfonomides
inhibit synthesis of DHA