lecture 21 Flashcards
1
Q
EGFR
A
epidermal growth factor receptor
2
Q
what happens when the EGF binds to the recptor
A
they come together
dimerise
3
Q
what happens to EGFR when its dimerised
A
activated and causes ATP to be taken in
4
Q
what happens when the ATP enters the cell due to EGFR
A
survival of cancer cell
5
Q
tumour cell heterogeneity
A
varying parts of the same tumour
6
Q
what does gefitinib inhibit
A
EGFR
7
Q
what does exon 19 affect
A
ATP binding
8
Q
who responds well to gefitinib
A
people with a mutation of exon 19
9
Q
what blocks the binding of getfitinib
A
a secondary mutation called T790M
