lecture 15 parasitic infections Flashcards
what kind of parasite is malaria
protozoan
what are the two main types of parasite
helminth and protozoan
what are helminths and protozoa …karyote
eukaryotes
how many cells do protozoa
unicellular
what are helminths
worms
what do helminths produce to reproduce
eggs
what might it be hard to find drugs for parasites
they are also eukaryotes
what is the drug target for helminths
neuromuscular system
what happens when the trugs target the helmiinths
paralysis
why are the current anitmalarials becoming ineffective
resistance
vector for malaria
anopheles
in malaria where does the parasite affect
liver and blood
how does the parasite get from mosquito to human
bites
injects sporozites
where do the sporozoites first go
the liver
how long do the sporozoites remain in the liver
10 days
what do they do in the liver
mature to form schizonts
what do the schizonts form
merozoites
how do the merozoites get into the blood
make the liver cell they are in burst
in the blood what do the merozoites mature into
trophozoites
where does sexual reproduction occur in the mosquito
stomach
what does the zygots in the mosquitos stomach form
it matures into ookinete
what does oopinete do
moves from stomach to midgut and here produces sporozoites which go to the salivary glands
when do you start feeling sick if you have malaria
when it gets into the blood
where do mosquitos undergo asexual reproduction in the human
blood cells
how long is the peak of fever in malaria
4 days
what are the three big groups of malaria chemo
quinolines
antifolates
artemisinin
how does chloroquine work
blocks the parasite detoxification of heme
how do antifolate drugs work
affect folic acid metabolism of the parasite
what is sleeping sickness also known as
African trypanosomiasis
what type of parasite is African trypanosomiasis
protozoan
what is the vector for African trypanosomiasis
tsetse fly
what can the African trypanosomiasis cross
blood brain barrier
what kind of problems do African trypanosomiasis cause
neurological
South american trypanosomiasis is also called
chagas disease
what is the vector for south american trypanosomiasis
triatomine insects
what part of the body do triatomone insects tend to bite
the face
what is Leishmaniasis transmitted by
female sandflies
what does Leishmaniasis do
invades macrophages
who does toxoplasmosis affect
the immunocompramised
what does toxoplasmosis cause
mild lymphadenopathy
giardiasis is
diarrheal disease
how does prazinquantel work
paralyses the worms
where does ascariasis live
intestines
