lecture 16 general cancer Flashcards
what are the two types of regulatory genes that lead to cancer
proto-oncogenes
tumour supressor genes
what happens to proto-oncogenes
they are mutted and become oncogenes
what do oncogenes do
drive proliferation
what do tumour supressor gene usually control
DNA repair
cell death
what is EGFR
gene expressed all around the body
receptor for tyrosine kinase
what happens if EGFR is constantly active
drives cell proliferation
cell survival through apoptosis inhibition
what is a tumour suppressor gene
any gene which supresses cell growth
what is li fraumeni syndrome
heterozygous loss of p53
example of a main tumour suppressor gene
p53
example of inhierited cancer geene
BRCA
what does a mutation in the BRCA gene cause
breast cancer
what type of gene is the APC gene
oncogene
what does a mutation of the APC gene cause
adenomas in the colon
what cancer can asbestos cause
mesothelioma
human papilloma virus
oncogenic
DNA virus
helicobacter pilori is gram
egative
metaplasia
transformation of one mature cell into another
how can acid reflux be linked to cancer
can cause metaplasia in the oesophagus
why do cancers want blood supply
to spread
whats an adenoma
benign neoplasm of cells
what is a carcinoma
malignant epithelium neoplasm
what type of carcinoma does glandular epithelium cause
adenocarcinoma
what do connective tissue malignant tumours end in
sarcoma
teratoma
cantains all three egerm layers
