Lecture 6 Unit 1 Flashcards

1
Q

how do oxygen and nutrients move out of the blood?

A

by crossing the capillary wall and entering the interstitial fluid (ISF)

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2
Q

how do carbon dioxide and metabolic waste products move?

A

in the opposite direction

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3
Q

how long would body capillaries be if they were placed end to end?

A

60,000 miles and cross sectional area would be 5,000 cm^2

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4
Q

how long is the average capillary? and the lumen diameter?

A

capillary- 1 mm

lumen- 8 micrometers

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5
Q

what is the blow flow velocity in a capillary?

A

0.1 cm/sec

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6
Q

what is the concentration or density of capillaries in a given tissue proportional to?

A

the tissue’s metabolic activity

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7
Q

what does the term capillary bed refer to?

A

a network of capillaries where exchange of materials with the tissue cells can take place

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8
Q

how far is every cell tissue usually from a capillary?

A

~1.3 cell diameters

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9
Q

when is diffusion efficient?

A

only when diffusion distances are short

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10
Q

how do most substances move?

A

by diffusion

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11
Q

what can cross intercellular clefts?

A

pores, water and most small substances cross the capillary wall by diffusion through these pores

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12
Q

what can cross endothelial cell membranes?

A

some small molecules and gases can diffuse or be transported across the endothelial cell layer

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13
Q

what can cross fenestrations?

A

large molecules can pass easily through the fenestrations

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14
Q

what are the 3 routes for capillary exchange?

A
  • intercellular clefts
  • endothelial cell membranes
  • fenestrations
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15
Q

where are continuous capillaries found?

A

found in lungs, skeletal muscle, and connective tissue

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16
Q

where are fenestrated capillaries found?

A

kidneys, endocrine glands, small intestine

17
Q

what does fenestration mean?

A

little windows (70-100 nm)

18
Q

where are sinusoidal capillaries found?

A

liver, spleen, bone marrow, and anterior pituitary gland

19
Q

What two ways do materials pass through capillary walls?

A

active or passive transport

20
Q

what is diffusion?

A

movement of molecules or ions from a region of higher concentration to one of lower concentration until equilibrium is reacher

21
Q

is diffusion passive or active?

A

passive

22
Q

what is bulk flow?

A

bulk flow refers to the movement of a fluid from a region of higher pressure to one of lower pressure

23
Q

is bulk flow an active or passive process?

A

passive

24
Q

what is transcytosis?

A

substances enter pinocytotic vesicles, move to endothelial cells via endocytosis, and exit on opposite side via exocytosis

25
Q

is transcytosis active or passive?

A

active

26
Q

What is fluid exchange between ISF and capillaries based on?

A

bulk flow

27
Q

what are the two major forces that tend to push fluid out of capillaries and into ISF?

A
  • blood hydrostatic pressure

- interstitial fluid osmotic pressure

28
Q

what does blood hydrostatic pressure (BHP) do?

A

pushes fluid out through the capillary pores

29
Q

what does interstitial fluid osmotic pressure (IFOP) do?

A

pulls fluid out via osmosis; this pressure is very small compared to the BHP

30
Q

what are the two forces that pull fluid INTO the capillaries?

A
  • blood colloid osmotic pressure (BCOP)

- interstitial fluid hydrostatic pressure

31
Q

what does blood colloid osmotic pressure (BCOP) do?

A

the BCOP is the result of differences in protein concentration between plasma and ISF which tends to pull water from the ISF and into the capillaries

32
Q

what is the interstitial fluid hydrostatic pressure (IFHP)?

A

the IFHP is due to the pressure exerted by interstitial fluid, but it is normally very small

33
Q

what is the net filtration pressure?

A

the difference between the inward and outward pressures

34
Q

what is the equation for the NFP?

A

NFP= (BHP + IFOP) - (BCOP+IFHP)

35
Q

what determines the fluid movement across the capillary wall?

A

the BHP and BCOP

36
Q

what does filtration result in?

A

a constant flow of fluid that washes over the tissue cells at the arterial end of the capillary carrying nutrients and oxygen with it

37
Q

what does reabsorption result in?

A

a return of fluid to the capillary at the venous end, herby depositing wastes into the venous system

38
Q

under normal conditions how much fluid leaves the capillaries?

A

slightly more fluid leaves than enters the capillaries (3L/day)

39
Q

what do the lymphatic vessels do?

A

they absorb this excess fluid and return it to the circulatory system