Lecture 18 and 19 Unit 3 Flashcards
what are immune responses
altered cellular reactions following contact with a component of a specific foreign organism/product or antigen
how is adaptive immunity distinguished from innate immunity
- specificity for particular foreign molecules and tolerance for self proteins
- memory of perviously encountered foreign antigens so that the second exposure prompts a more rapid and vigorous response
what are the two types of adaptive immunity
- cell-mediated immunity
2. antibody mediated immunity
what does cell mediated immunity depend on
T cell receptors (TCRs) that are expressed on the surface of T cells
what does cell mediated immunity do after recognizing foreign antigen presented by MHC I proteins?
defends the body against specific pathogens that live/exist inside of our cells by recognizing only foreign antigen presented by MHC I proteins
what does cell mediated immunity do by not recognizing self-antigen presented by MHC I proteins?
is becomes tolerant of our own proteins
what does antibody mediated immunity depend on
T cell receptors that are expressed on the surface of T cells in addition to other proteins used by B cells
by recognizing foreign antigen that is processed then presented by MHC II proteins what does antibody mediated immunity do?
defends the body against specific pathogens that live/ exist outside of our cells
by not recognizing self-antigen presented by MHC II proteins, what does antibody mediated immunity do?
become tolerant of our own proteins, nucleic acids, lipids, and polysaccharides
what are the two properties of antigens
- immunogenicity
2. reactivity
what is immunogenicity
antigens stimulate proliferation of specific lymphocytes and antibodies
what is reactivity
antigens react with activated lymphocytes and antibodies developed/released in response to them
what do complete antigens exhibit
both properties and include foreign proteins, nucleic acids, some lipids, and large polysaccharides
what are immune responses generated against
parts of antigens called epitopes
after leaving the thymus what does tight binding mean?
recognition of a foreign antigen
what are the 5 steps in which cell mediated immune response occurs
- antigen presentation
- antigen recognition
- activation
- proliferation and differentiation
- action (destrcution of infected cell)