Lecture 6 Flashcards
What oxygen use class is Strep Pyogenes found in?
Strep Pyogenes is a MicroAeroPhilic bacterium
Can Strep use Oxygen?
NO, MicroAeroPhilic=no Resp!!
What does the word Pyogenic mean?
Pyogenic= “Pus Forming”
What does a decorated crab have to do with Strep pyogenes?
It can disguise itself from our immune sys
What is the END result of superantigen of Strep Pyogenes?
Scarlet Fever
What is another name for enzymes secreted by both strep and staph causing cellulitis?
F.E.B.!!! Flesh Eating Bacteria
What are the three ways we can classify a Strep member?
1.Hemolysis (beta, alpha, gamma) 2.Its Lancefield CHO Antigens (A,B) 3. Its Natural Clusters/loactions
What is the beta-hemolytic strep’s affect on RBCs?
COMPLETE hemolysis
What is the alpha-hemolytic streps affect on RBCs?
Changes Hemoglobin shape and therefore changes its color to GREEN!
What is the gamma-hemolytic strep affect on an RBC?
NOTHING!
S. Lactis =
Lactics Strep
E. Fecalis, E. Faecium, E. Bovis, E. Swis=
Enterococci Strep
S. Pyogenes, S. Agalactiae, S. Pneumonia=
Pyogenic Strep
S. Mitis, S. Salivarius, S. Mutans=
Viridans Strep
What are the MAJOR bacterial species found in the oral cavity?
alpha-hemolytic viridans strep
What is G.A.S. (group-a-strep), has many toxins, and causes step throat, rheumatic fever, cellulitis, and scarlet fever?
Strep Pyogenes
What is Beta-hemolytic, has a Capsule, and causes neonatal sepsis (birth canal flora)? (hint: battle star galactitca)
S. Agalactiae
What is alpha-hemolytic, has a capsule, and causes MENINGITIS, pneumonia, and ear infections?
S. Pneumoniae
What is alpha-hemolytic and can cause SUB-acute endocarditis, caries?
Viridans strep
Which hypersensitivity type is most serious?
Type I
How would repeated Strep occur?
The M protein presented by Strep becomes altered
What are cyclic toxins produced by strep that can kill leukocytes?
Strepto-Lysin
How can strep INACTIVATE the C5a “911” molecule?
Using C5a peptidase
What are the THREE approaches for strep to damage the host?
1.Pyogenic Infection 2.Toxic Systemic 3.Immune Sequelae Disease
What is the skin manifestation of BOTH Strep AND Staph pyogenic infection?
Impetigo
What are the three main strep pyogenic/LOCAL infections?
Strep Throat, Impetigo, and Cellulitis
What are the two main toxic systemic diseases of strep?
Scarlet Fever and Strep Toxic Shock Syndrome (STSS)
What are the two main Sequelae diseases of strep? What are their sensitivity types?
Rheumatic Fever (Type II), and Glomerulonephritis (Type III)
Which of the three exotoxin classes is at the root of Scarlet Fever and Strep Toxic Shock-LIKE Syndrome? (end result is a cytokine storm)
Superantigen! (Toxin “glues” TCR’s to Class II MHCs)
Which Type of hypersensativiy has to do with the coke bottle and the water bottle looking similar and therefore the body mounts a response agains both pathogen and self receptors?
Type II…..Think Two bottles!
What type of hypersensitivity is caused by the formation of complexes that can gather “like leaves on the storm drain during the fall?” (which then macrophages come and indescriminantly eat)
Type III…Think Fall is the third season
Which is generally more resistant to antibiotics: strep or staph?
Staph is generally more resisstant
NO CARDS ON ACUTE VS SUBACUTE
MAKE SOME LATER?
