Lecture 4 Flashcards
What part of our innate immune system is like T2?
The epithelium, because it can self heal
Is the INNATE immune system: Broad or Specific?, Fast or Slow? Memory or No Memory?
Innate=Broad, Fast, and No memory
Is the Adaptave Immune system: Broad or Specific? Fast or Slow? Memory or No Memory?
Adaptave=VERY specific, Slow (days), and YES it has memory!
What are these examples of?: Macrophage, Kuppfer Cell, Dendritic Cell, Glial Cell, Alveolar, Neutrophil (large bone, marrow pool)?
PROFESSIONAL Phagocytes
How often do new lymphocytes emerge?
Daily!
What is the look out/first cell to initiate an inflammatory response? What does it use to signal other cells?
Mast Cell! It signals with Histamine release.
What antibodies are present on Mast Cells?
IgE…EyEs!! Looking out for insults!
Along with Mast cells what are the other markers of Acute inflammation?
Mast, Plasma Proteins, and NEUTROPHILS (the HALLMARK of acute inflammation!)
What are the 2 immediate effects on the blood vessels of mast cell histamine release?
- Blood Vessels relax (Heat, Redness) 2. Vessels open (Swelling/edema)
In inflammation, after the vessels open and become leaky, what do we use to STOP WBCs?
Histamine stimulates endothelial cells to present CAMs (cell adhesion molecules)
What are the three markers of chronic inflammation?
Cell Proteins, Lymphocytes!!!!, and Macrophages
Why does the brain cause Fever?
It knocks the pathogen off stride
What does the liver do in response to inflammation?
It Synthesizes the defense molecules!
What does the bone marrow do in response to inflammation?
It stimulates more immune cell production
Where are lymphocytes born? (BE SPECIFIC)
PRIMARY Lymphoid tissue (2): 1. B-Cells, Bone Marrow 2.Thymus (YES still Primary lymph tissue)
What are the secondary lymphoid organs? (3)
1.Lymph Nodes 2.Spleen 3.Tonsils
Which structure is like the singles bar? Why?
The lymph node, the pathogen gets crammed into the node and bumps into lots of different immune cells..SWAMP analogy too
CRAZY! The lymph system altogether has a larger mass then the….?
Brain!! Awesome to think about!
Which lymph tissue does education occur?
Primary Lymph Tissue
What do B Cells initially use to identify a pathogen? What do they make once they find their pathogen?
B-cell Receptor (BCR)…They then make copies of the BCR, but now they are called antibodies
What do T cells use to recognize a pathogen is around (not directly on the pathogen)? What does it release in response?
T cells use T-Cell Receptors (TCR) and then release CytoKines
What is the small region of the antigen that actually binds to a B or T cell antigen receptor?
An EpiTope!
What antigen binds to any ole cell to THEN relay the info to a T-cell?
HLA presenter protein
What is the process of coating antigens with antibodies to enhance phagocytosis?
Opsonization
What are the receptors on phagocytes that bind the suitcase handle on the pathogen?
The Fc Receptor of the phagocyte binds to the Fc region or the antibody(suitcase holder)
