Lecture 5 Flashcards
What are the three types of ExoToxins?
- Cytolytic 2. AB exotoxins 3.SuperAntigens
What is the MOST poisonous exotoxin class?
AB exotoxins!
What are two results from DIC (disseminated intravascular coagulation)?
Multiple Organ Shutdown and Acute Respiratory Distress Syndrome (ARDS)
Which cascade molecules stimulate Mast cells?
C3a and C5a
What type of exotoxin disrupts cell membranes by forming pores or cleaving the phospholipid portion of the cell membrane?
Cyto-Lytic toxins
What main exotoxin category do hemoLysins and LeukoCidins?
Cyto-Litic toxins
Which protein of the AB complex BINDS to the target cell?
B, as in BIND!
Does the A unit of the AB complex get used up?
Nope, so it can kill an entire cell!
How many people can be killed with 1 gram of Botulinum toxin? What class of exotoxin is it?
It is an AB exotoxin, it can kill 10,000,000 people!!!!!!
Which AB toxin cleaves ribosomal RNA and therefore blocks ribosome function?
Shigella
Which AB exotoxin uses NADH to add ribose to elongation factor and therefore blocks protein synthesis?
DiphTheria
Which AB exotoxin uses NADH to add ribose to G-Proteins?
Cholera
Which AB exotoxin toxin blocks release of inhibitory mediators by intermediate neurons, permitting muscle neurons to continue to fire causing continuous muscle constriction?
Tetanus toxin
Which AB exotoxin toxin blocks vesicles with acetylcholine mediator from fusing with the muscle synapses, thus blocking muscle action, leading to flaccid paralysis?
Botulism Toxin
Which exotoxin inappropriately binds the Thelper cell TCR to HLA class II molecule on AntigenPresentingCells, initiating Thelper cell/macrophage activation? WHAT is the FINAL Result??
This is SuperAntigen Exotoxin, the FINAL result is A CYTOKINE STORM!!!
