17-the HEP viruses Flashcards
Which hepatitis viruses are NON-enveloped and therefore transmitted fecal-orally?
Hep A and Hep E
Which hep viruses cause acute infection?
Hep A and Hep E
Which hep viruses are enveloped and therefore transmitted through blood?
Hep B,C,D
Which hep viruses cause chronic infection?
Hep B,C,D
Which Hep have vaccinations?
Hep A, B, *D-thru B vaccination!
Which Hep’s do not have vaccinations?
Hep C,E
What is the liver enzyme that is released upon damage to the liver?
Transaminase (SGOT)
Can you diagnose Hep infection with Jaundice?
Nope, only 25% of hep peeps get jaundiced
Which Hep virus have most of us probably caught because it is easily transmitted, acute and there are no carriers?
Hep A
Which hep does a classmates family member have that the drugs cost $1000/day?
Hep C
Which hep is associated with preg women in the third world and carries a 20% mortality rate?
Hep E
Which family does Hep A belong to?
PicoRnaViridae
Why can I deduce that there is a vaccine for Hep A? What type of vaccine is it?
Because there is only a single “SEROtype”…It is an inactivated (not killed i guess) vaccine
What is the most popular method to treat a Hep A infection?
Pooled IgG (from a blood donor)
Which region of the US was Hep A a problem?
West! AZ especially!!
What family of virus is hep B?
HepaDnaViridae…our first one!
Is there a single serotype for Hep B?
yes, therefore a Vaccine is available!
How is Hep B transmitted? (think structure!)
Blood, sex, birth
What was the highlighted mode of transmission for Hep B?
B for Birth!
What % of neonates become infected with Hep B during birth?
90%!!
What is unique about the dose of Hep B?
There is a HUGE amount in the blood!
Even though Hep B is considered a “chronic” condition, what percent of carriers actually become chronic? THEN how much of them develop the bad stuff(cancer, cirrihosis) LASTLY, how does this differ from HCV?
5-10% become chronic, only 10-25% of THOSE 5-10% get the real bad stuff…..HCV 40-50% of the chronically infected develop cirrhosis and cancer
What are the two possible routes for Hep B dsDNA once in the cell?
1.Go straight to mRNA–>protein 2.Enter the host genome to make more mRNA/DNA
What are the three things the Dr looks for when deciding if a Hep B pt is “cured” or chronically infected? WHEN do they check these levels?
Cured: 1.High Anti-HbsAg 2.Low liver enzymes (transaminase) 3.low HbsAg(the HBV protein spike) Not Cured:opposite :)…..SIX MONTHS post infection
What are the 3 pieces of info for HDV?
- Has 1 gene! 2.Uses Hep B’s spike protein (HbsAg) 3.”a defective virus”
