17-the HEP viruses

Question 1

Which hepatitis viruses are NON-enveloped and therefore transmitted fecal-orally?

Answer 1

Hep A and Hep E

Question 2

Which hep viruses cause acute infection?

Answer 2

Hep A and Hep E

Question 3

Which hep viruses are enveloped and therefore transmitted through blood?

Answer 3

Hep B,C,D

Question 4

Which hep viruses cause chronic infection?

Answer 4

Hep B,C,D

Question 5

Which Hep have vaccinations?

Answer 5

Hep A, B, *D-thru B vaccination!

Question 6

Which Hep’s do not have vaccinations?

Answer 6

Hep C,E

Question 7

What is the liver enzyme that is released upon damage to the liver?

Answer 7

Transaminase (SGOT)

Question 8

Can you diagnose Hep infection with Jaundice?

Answer 8

Nope, only 25% of hep peeps get jaundiced

Question 9

Which Hep virus have most of us probably caught because it is easily transmitted, acute and there are no carriers?

Answer 9

Hep A

Question 10

Which hep does a classmates family member have that the drugs cost $1000/day?

Answer 10

Hep C

Question 11

Which hep is associated with preg women in the third world and carries a 20% mortality rate?

Answer 11

Hep E

Question 12

Which family does Hep A belong to?

Answer 12

PicoRnaViridae

Question 13

Why can I deduce that there is a vaccine for Hep A? What type of vaccine is it?

Answer 13

Because there is only a single “SEROtype”…It is an inactivated (not killed i guess) vaccine

Question 14

What is the most popular method to treat a Hep A infection?

Answer 14

Pooled IgG (from a blood donor)

Question 15

Which region of the US was Hep A a problem?

Answer 15

West! AZ especially!!

Question 16

What family of virus is hep B?

Answer 16

HepaDnaViridae…our first one!

Question 17

Is there a single serotype for Hep B?

Answer 17

yes, therefore a Vaccine is available!

Question 18

How is Hep B transmitted? (think structure!)

Answer 18

Blood, sex, birth

Question 19

What was the highlighted mode of transmission for Hep B?

Answer 19

B for Birth!

Question 20

What % of neonates become infected with Hep B during birth?

Answer 20

90%!!

Question 21

What is unique about the dose of Hep B?

Answer 21

There is a HUGE amount in the blood!

Question 22

Even though Hep B is considered a “chronic” condition, what percent of carriers actually become chronic? THEN how much of them develop the bad stuff(cancer, cirrihosis) LASTLY, how does this differ from HCV?

Answer 22

5-10% become chronic, only 10-25% of THOSE 5-10% get the real bad stuff…..HCV 40-50% of the chronically infected develop cirrhosis and cancer

Question 23

What are the two possible routes for Hep B dsDNA once in the cell?

Answer 23

1.Go straight to mRNA–>protein 2.Enter the host genome to make more mRNA/DNA

Question 24

What are the three things the Dr looks for when deciding if a Hep B pt is “cured” or chronically infected? WHEN do they check these levels?

Answer 24

Cured: 1.High Anti-HbsAg 2.Low liver enzymes (transaminase) 3.low HbsAg(the HBV protein spike) Not Cured:opposite :)…..SIX MONTHS post infection

Question 25

What are the 3 pieces of info for HDV?

Answer 25

1. Has 1 gene! 2.Uses Hep B’s spike protein (HbsAg) 3.”a defective virus”