Lecture 5 Flashcards
What is Membrane Permeability?
The net rate of diffusion of a given substance through each unit area of the membrane for a unit [] difference on either side.
What are the 5 factors affecting membrane permeability and why?
1) Membrane Thickness: Increased thickness, decreased diffusion rate
2)Lipid Solubility: Greater solubility, greater diffusion rate (hydrophobicity.. greater increased lipid solubility)
3) Number of Protein Channels: increased rate of transport with greater channel density (# channel/area)
4)Temperature: Diffusion increases in direct proportion with temperature.
5) Molecular Weight of Diffusing Substance; V = velocity of thermal motion (heavier substance will move slower)
What is exocytosis?
Movement from inside to outside of cell
What are the three functions of exocytosis?
1) Membrane Components
- Adds molecules from vesicle interior
- GLUT4 (monosaccharide)
2) Recycle Endocytosis Products (engulf)
- Adds to cell membrane
3) Secretion
- Interior to Exterior
- White blood cells for antibodies
- Neurons… release neurotransmitters
- Mucus…respiratory and digestive systems
What do Junctional Folds do?
Increase SA (membrane tissue)
What do vesicles house?
Neurotransmitters
What is a terminal axon?
A motor axon of motor neuron
What are the three types of transporters?
1) Uniporter
2) Symporter
3) Antiporter
What is a uniporter?
Transports only 1 solute (molecule or ion)
What is a Symporter?
A co-transporter - transport of 1 solute COUPLED to the transport of a SECOND solute in the same direction.
What is a Antiporter?
A exchanger - Transport of 1 solute coupled to the transport of a SECOND solute… in the opposite direction.
What is primary active transport?
- Harness stored chemical energy… ATP
- ATP used directly to move ions.. uphill (against a concentration gradient)
- Na+/K+ ATPase
What is secondary active transport?
Uses stored chemical energy.. ATP indirectly
Harnesses stored electrochemical gradient energy.
What is an example of an ATP pump?
SERCA (Sarco Endoplasmic Reticulum Ca++ ATPase
What are P-type Pumps?
- Phosphorylate themselves during cycle
- Ion pumps for NA+,K+, H+, Ca2+
- Uses ATP
- Primary Active Transport