Lecture 4

Question 1

Tissue regeneration

Answer 1

Complete reconstitution

• tissues with a high proliferative capacity
• requires viable stem cells and intact connective tissue scaffolding

Question 2

Tissue repair

Answer 2

Combination of regeneration and scar formation
-relative contribution of two processed. Depends on capacity to regenerate, extent of injury and extent of scarring/fibrosis

Question 3

Sequence of healing

Answer 3

Inflammation
Angiogenesis/neovascularisation
Migration and proliferation of parenchymal cells and fibroblasts
Scar formation
Connective tissue remodelling

Question 4

Healing by second intention

Answer 4

Larger scab (clot)
Inflammation more intense because there is more necrotic debris, exudate and fibrin to remove
Larger amounts of granulation tissue-larger defect
Involves would contraction