Lecture 11

Question 1

Small cell carcinoma

Answer 1

Strong link to smoking
Occur in bronchi and at periphery. Early mets. Responsive to chemo but relapses early
Small, tightly packed, darkly stained ovoid tumour cells. Resemble oats. Absent/inconspcuous nuclei

Question 2

Squamous cell carcinoma

Answer 2

Most commonly affects men. Close relationship to smoking. Arises close to hilum, usually in area of squamous metaplasia.
Well differentiated resembles stratifies squamous epithelium which is characterised by keratin formation and or bridges.

Question 3

Adenocarcinoma

Answer 3

Most common type in women and non-smokers.
Tends to be peripherally located
Grows slower than SCC but mets early and widely
Sometimes associated with scarring e.g TB
Well differentiated have obvious glandular elements
2/3 peripheral.

Question 4

Large cell carcinoma

Answer 4

Undifferentiated, malignant epithelial tumour.

Question 5

Pleural tumours

Answer 5

Secondary metastatic involvement more common than primary tumour. Most frequently breast or lung.
Primary tumour = malignant mesothelioma. Linked to asbestos.