lecture 2 skeleton Flashcards
some functions of skeleton
provide framework
allows motion through joints
provides muscle leverage
protects organs
axial skeleton
skull
vertebra
ribs
appendicular skeleton
scapular and arms
pelvis and legs
skeletal tissues are derived from
connective tissue
skeletal tissue
some are non-mineralized (lack hydroxyapatite)
- notochord
- cartilage
Some are mineralized
(have hydroxyapatite)
-calcified cartilage
-bone
mineral that allows for mineralization
hydroxyapatite
describe notochord
non mineralized (no hydroxyapatite)
source of developmental signaling
in vertebrates, becomes nucleus pulposus in each intervetebral disc
what does notochord turn into in vertebrate adults
nucleus pulposus of the intervertebral disc
Cartilage
non mineralized (lack hydroxyapatite)
composed of
- gel matrix (chondromucoprotein and water)
- collagen or elastic fibers
- chondrocytes (cartilage cells)
no blood supply or innervation
flexible
easy to injure, difficult to reapir
growth tissue in fetus and juvenile
in adults- ears, nose, larynx and joints
cartilage cells
chondrocytes
gel matrix of cartilage is made of
chondromucoproteins and water
where is cartilage in adults
ears, nose, larynx and joints
Calcified Cartilage
mineralized (hydroxyapetite in gel matrix)
-tissue hard, brittle and opaque
unorganized microstructure
-minerals added randomly between cartilage cells
stronger than cartilage
transitional tissue
where is calcified cartilage found
shark vertebrae
horse larynx
deepest articular cartilage
calcified cartilage is stronger than ___ but harder to heal because ___
cartilage
hydroxyapetite blocks diffusion of things needed to heal area
Bone is made of
organic and inorganic components
organic components of bone
osteroids
- type 2 collagen and bone matrix proteins
- hormone osteocalcin
- 20-25% bone weight
cells -some from mesenchyme =osteocytes =osteoblasts -some from hematopoietic tissue -osteoclasts
type of bone cell from mesenchyme
osteocytes
osteoblasts
types of bones cells from hematopoietic tissue
osteoclasts- break down bone
type of cells that break down bone
osteoclasts
type of cells that create bone
osteoblasts
Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton
inorganic components of bone
hydroxyapatite
- how bones mineralize
- 60-70% of bone weight
Water
Bone only grows at ___ and is ___ throughout life
at surface
remodeled
Bone has a nerve and blood supply that travels through ___
haversian canals
minerals that are reserved in bone
Calcium
Phosphorous
Potassium
making of blood cells in ___ inside bone core is called ___
red marrow
hematopoiesis
during growth, red marrow is ___ by fat and becomes ___
replaced
yellow marrow
What hormone does bone release
osteocalcin
what does osteocalcin do
- insulin regulation
- brain development and function
- testosterone formation and release
round layered formation of bone
osteon
layers of an osteon
lamellae
small cellular processes that connect osteocytes to each other
canaliculi