Lecture 18.1: Influenza Assembly and Egress

Question 1

non-enveloped progeny viruses escape the cell by __

Answer 1

apoptosis

Question 2

enveloped progeny viruses escape the cell in the course of acquiring their __

Answer 2

lipid envelope

Question 3

what are the 2 way sin which progeny viruses can acquire their lipid envelopes?

Answer 3

1. by budding into internal membrane followed by exocytosis

2. by budding directly from the plasma membrane

Question 4

when a virus uses egress by apoptosis, it is very important to ensure it is done at the right __

Answer 4

time

Question 5

herpesvirus capsids are enveloped ___ (inside / outside)

Answer 5

inside

Question 6

herpesvirus use the ___ pathway for egress

Answer 6

normal protein secretory

Question 7

in preparation for budding, the virion proteins assemble at the __

Answer 7

plasma membrane

Question 8

route of transmission for influenza

Answer 8

respiratory, direct person-person contact or by aerosol

Question 9

what are the target cells of influenza virus?

Answer 9

epithelial in respiratory and alveolar macrophage

Question 10

what is the cell receptor for influenza virus?

Answer 10

sialic acid

Question 11

what type of genome does the influenza virus have?

Answer 11

-ssRNA

Question 12

_ segments code for __ proteins

Answer 12

8; 11

Question 13

RNA dependent RNA polymerase makes +ssRNA from template -ssRNA and does what 2 things with it?

Answer 13

1. exports to the cytoplasm and translated

2. used as template for progeny -ssRNA

Question 14

the rapid evolution of the virus the allows it to evade the host immune system is called __

Answer 14

antigenic drift

Question 15

antigenic shift

Answer 15

co-infection with different strains can result in reassortment of genome segments that makes a new highly virulent and pathogenic strain