lecture 17.2 Acyclovir and Herpesvirus Flashcards
what is the structure herpes simplex virus?
enveloped with gycloprotein spikes
what is the genome type of herpes simplex virus
ds rna
what is in the tegument space of herpesvirus and what is the function?
all the good stuff that will sustain the virus in the early stages of replication
how are epithelial cells and neutrons targeted by herpesvirus?
through receptor interactions between viral glycoproteins and and host cell surface proteins
the initial attachment of HSV-1 glycoproteins to cell surface glycosaminoglycans is __ (reversible / irreversible )
reversible
the stable binding to the receptor is __
reversible
what brings the viral envelope and cell membrane close together?
a conformational change
what causes fusion of the virus envelope with the cell membrane to allow entry of herpesvirus?
lipid mixing
how does herpesvirus express their its genes?
host rna polymerase 2
how does herpesvirus duplicate its genomes?
viral dna dependent dna polymerase
where in the cell does herpesvirus gene expression and genome replication take place?
in the nucleus where the host rna polymerase lives
acyclovir is used as treatment for __ and __
HSV-1 and VZV
acyclovir structurally mimics __ but is missing __
guanosine; bottom part of sugar
target of acyclovir and how it does that
viral dna replication; by acting as a chain terminator
t/f acyclovir is a pro-drug
t
