Lecture 13 - Pharmacology and drugs in sport Flashcards
What is parmacokinetics?
how body affects drug
What is pharmacodynamics?
how drug affects body
What factors affect metabolism of a drug?
- genetics
- druge interaction (smoking)
- age
- liver disease
- renal disease
- alcohol
- smoking
- nutrition
What is the therapeutic window?
The period window in which a drug is causing the desired response
therapeutic window
What is the lower limit?
concentration that produces half the greatest possible effect
Therapeutic window
What is the upper limit?
no more than 5-10% of patients experience a harmful side effect
What are the pharmacokinetics of tylenol?
- high absorption in SI
- metabolism in liver
- time peak is 10-60 minutes
- half life is 2-3 hours
- elimination through urine mostly as metabolites
What is tyelnol used for?
pain and fever
What are the pharmacokinetics of NSAIDS?
- absorbed rapidly from stomach and upper SI
- time to peak is 1-2 hours
- distribtution through most body tisseus
- metabolized in liver
- excreted through urin
- half-life 2hrs
What are possible side effects of NSAIDS?
stomach - nausea, pain, gastritis, ulcer/bleeding
kidneys - hypertentiosn, fluid retention, renal failure
plateletes - dysfunction that inhibits clotting
vessels - vasocontristcion (hypertentsion)
tinnitus
What are NSAIDS used for?
pain, fever, anti-inflammatory
What are NSDAIS implications for injury?
- can inhibit protein synthesis and muscle repair
- can inhibit tenocyte proliferation and collagen formation
What is cortisone used for?
pain, anti-inflammatory
What are some possible implications for injury when using cortisone?
- inhibit collagen synthesis
- achilles and patellar tendionapathies
- damage to cartilage/tendon\infection
- tendon rupture
What is the pharmacokinetics of opiods?
M-opiod receptor agonist
