Lecture 13 Flashcards
How does DNA damage occur? What happens if its passed onto future generations
What are the 3 steps for unrepaired mutations becoming a permanent part of the genome?
What is an example of a mutation? How does it happen?
What is responsible for proofreading the DNA? What are the mechanism to repair the damage?
What does the replication bubble create? What is the solution to the problem?
What does MMR do? How does MMR discriminate between the mother and daughter cell?
What are the 4 steps involved with MMR? What is the complex involved? When does this occur?
What happens if there is a mutation in MSH1 or MSH2?
How are single strand damages repaired? How are double strand breaks repaired?
How is base excision repair initiated? What are 3 types of glycosylases?
What is an example of base excision repair and what are the 4 steps to fixing the problem?
What does Nucleotide excision repair do? What are the 4 steps of NER?
How are single-strand damages repaired? What are the common/ shared mechanisms?
What is non-homologous end joining? What is it used to fix? What is the complex that helps?
What is homologous recombination? When is HR generally used? What is used to repair the damage?
What are the genes BRCA1/ BRCA2? What do they do? What happens if they aren’t working properly?
What are some endogenous sources of DNA damage? What are some exogenous sources?
What is spontaneous deamination? What is the solution? What is the repair mechanism?
What does DNA damage by base hydrolysis result in? How is it repaired?
What are reactive oxygen species? How are they repaired?
How does UV radiation damage DNA? How is it repaired? Two adjacent pyrimidine bases on the same strand become linked to create a ________________
What is Xeroderma Pigmentosum? What is the defective repair mechanism? What does it cause?
What are carcinogens? What are DNA adducts? How are they repaired?
How is single strand damage repaired? How are links between adjacent bases repaired? Oxidation? DS breaks? Deaminated base? Missing base? DNA adduct?
Give me a summary of DNA repair mechanisms
