Exam3-L30/31- Lipid metabolism Flashcards
What are the 3 services in a fasted state?
What is the big picture for adipose/ muscle/ liver in a fasted state?
What is the when/where/what/why for lipolysis? What is the rate limiting enzyme? What are the products and their fates? How many fatty acids are typically liberated?
What turns hormone sensitive lipase on/off? What inhibits HSL?
Q1-D/B
How are FFA’s released from adipose carried in the blood? How do they enter cells? How are fatty acids activated?
What is the when/where/what/why of beta oxidation? What is the rate limiting enzyme? What are the products and their fates?
How is CPT-1 transported? CPT2? What is an allosteric inhibitor of CPT1?
What does beta oxidation do to the fatty acyl chain? What are the products? What are their fates? What happens with odd-chain fatty acids? What does the last step do? What happens to Propionyl-Coa?
Q1-A/C
What is the when/where/what/why of ketogenesis? What is the rate limiting enzyme? What are the products and their fates?
Rate limiting enzyme of ketogenesis- what is the starting substrate? What happens to the TCA cycle in the fasted state? What is the RLE controlled by?
Ketone oxidation (ketolysis) in extrahepatic tissues- What does the liver do with ketones? What do untreated diabetics display? What is the domino effect of the fasting state?
What is Jamaican vomiting sickness?
Q3:
Q4:
Q5:
Describe a summary for Lipolysis, Beta oxidation, and ketogenesis.
What is the what/why/when/where/who/how of lipogenesis?
What is the big picture of de novo FA synthesis and TAG synthesis?
De novo FA synthesis- What happens with Acetyl-CoA?
De novo FA synthesis- In the fed state what drives the movement of citrate from the mitochondria to the cytoplasm? How is it sustained?
Stage 1- what does ATP citrate lyase do? how is it regulated? What is ACC?
What are the first 2 ways ACC is regulated?
What is the 3rd way ACC is regulated?
What is fatty acid synthase? What is the reaction? What does Malonyl-CoA contribute?
What is Malic enzyme? What does the HMP oxidative branch do?
How is fatty acid activation accomplished? How is elongation and desaturation accomplished?
What are 2 ways the liver produces glycerol 3-phosphate? How is it produced in adipose tissue?
How are TAGs synthesized?
How are VLDLs synthesized? What do they transport?
Compare and contrast beta oxidation with de novo FA synthesis.
Explain whats going on here
