Exam 2- Drugs

Question 1

Fluoroquinolones

Answer 1

Antibacterial DNA inhibitors, inhibit DNA gyrase and Topoisomerase 2

Question 2

Acyclovir

Answer 2

DNA replication inhibitor for viral infection (HSP1/2)

Question 3

Rifampin

Answer 3

TB- Binds beta subunit of RNA polymerase preventing it from leaving promotor

Question 4

Puromycin

Answer 4

Inhibits elongation on bacteria by resembling aminoacyl tRNA

Question 5

Chloramphenicol

Answer 5

Binds to large subunit and inhibits formation of peptide bond

Question 6

Erythromycin

Answer 6

Binds to large subunit and prevents translocation from the A to the P site

Question 7

Tetracyclines

Answer 7

Blocks access of the aminoacyl tRNA to the A site

Question 8

Streptomycin

Answer 8

Affects initiation phase! Changes shape of small subunit, causing code on mRNA to be read
incorrectly

Question 9

Byetta

Answer 9

Incretin mimetic and DPP4 inhibitor (T2DM)

Question 10

Bortezomib

Answer 10

Proteasome inhibitor, used when things are getting degraded that shouldn’t be

Question 11

HNPCC

Answer 11

Caused due to MMR errors- progresses adenoma to carcinoma

Question 12

Beta- thalassemia

Answer 12

Hereditary anemia disease from incorrect splicing

Question 13

Fragile X

Answer 13

CGG repeats (argenine)

Question 14

Myotonic dystrophy

Answer 14

CUG repeats (serine)

Question 15

Familial Amyloid Polyneuropathy

Answer 15

Treated by siRNA

Question 16

Von Hippel disease

Answer 16

E3 ligase not targeting hypoxia inducing factor (increased tumor activity)

Question 17

DiGeorge syndrome

Answer 17

Recognized by FISH, small chromosomal deletion