Lecture 12.2

Question 1

What was jake (jamacian Ginger)

Answer 1

80-85% alcohol - legal in prohibition, caused motor control disordered and inpotence when TOPC was added

Question 2

MPTP has also been the cause of a ..

Answer 2

gait problem - a by product of incorrectly synthesising drugs

Question 3

MPTP is not toxic, but can cross the ___

Once inside the brain, can form ___

___ kills dopamine-producing _____ in substantia nigra

Answer 3

MPTP is not toxic, but can cross the BBB

Once inside the brain, can form MPP+

MPP+ kills dopamine-producing neurons in substantia nigra (high affinity uptake process)