Lawsonia and Moraxella Flashcards
General characteristics of Lawsonia intraceullularis
slender, curved gram neg rod
obligate intracellular pathogen
What does Lawsonia intraceullularis cause?
acute hemorrhagic syndrome
subclinical conditions releated to poor production
proliferative enteropathy
What are the disease forms of Lawsonia intraceullularis in pigs?
acute: porcine hemorrhagic enteropathy
chronic: porcine intestinal adenomatosis
Clinical signs of Lawsonia intraceullularis
mostly subclinical
mild diarrhea
reduced weight gain
Diagnosis of porcine intestinal adenomatosis
bacteria detection in feces
histochemical and immunohistochemical detection
detection of IFN-y
detection of IgG
What disease does Lawsonia intraceullularis cause in horses?
equine proliferative enteritis - common in weanlings 4-7 months old
Clinical signs of equine proliferative enteropathy
diarrhea, depression, fever, reduced appetite, weight loss, swelling of abdomen and lower limbs, poor hair coat, intermittent colic
Diagnosis of Lawsonia intracellularis
histopathology, PCR, tissue culute, chick embryos
Treatment of Lawsonia intraceullularis
tetracyclines
erthromycine + rifampin
tylosin in feed prophylactically
Is there a vaccine available for Lawsonia intraceullularis?
yes - live avirulent oral vaccine
reduces severity of disease
What disease is caused by Moraxella bovis?
infectious bovine keratoconjunctivitis - pink eye
General characteristics of Moraxella
gram neg coccobacilli in pairs
aerobic
non motile
Does Moraxella require enriched media?
yes - containing blood or serum
Virulence of Moraxella
fimbriae
Pathogenesis of M. bovis
bacteria adhere to cornea
pitting
edema and lymphocytic infiltration
sloughing of tissue
ulcers
photophobia
discharge
Transmission of M. bovis
direct contact
aerosol
mechnical vectors
perpetuated with UV rays, tall grass
concurrent mycoplasama a/o viral infections
Diagnosis of M. bovis
gram staining of lacrimal discharge
culture
PCR
fluorescine dye
Treatment of M. bovis
susceptibility testing
long-acting oxytetracycline IM
oxytetracycline in feed
ceftiofur SC
florfenicol IM
topical gentamicin
subconjunctival penicillin antibiotics
eye patches
Is there a vaccine for M. bovis?
yes - efficacy is not great
