LAB4 - necrosis and inflammation

Question 1

• ____is the sum of the morphologic changes that
  follow cell death in a living tissue or organ.

Answer 1

Necrosis

Question 2

It is the major
morphological manifestation of cell death

Answer 2

necrosis

Question 3

appearance of necrotic cells

Answer 3

The dead cells usually shows eosinophilia.

It may have a
“glassy” homogenous appearance as compared to normal
cells.

Question 4

types of necrosis

Answer 4

coagulative
liquefactive
caseous
fibrinoid
fat
grangrenous

Question 6

describe the characteristic of cells and structure of coagulative necrosis

Answer 6

the nuclei of the myocardial fibers are being lost

cytoplasm is losing its structure because no well-defined cross striations are seen

Question 7

when there’s a marked cellular injury, there will be an either ___ or ___

Answer 7

cell death or necrosis

Question 8

describe the microscopic appearance of a coagulative necrosis found in heart that suffered myocardial infarction

Answer 8

mess as many cells have died

the tissue is not recognizable

many nuclei have undergone pyknosis, karyorrhexis, karyolysis

the cytoplasm and cell borders are no longer recognizable

Question 9

the slide of a liquefactive necrosis shows

Answer 9

clear space on a certain area of a slide and blackening

the clear space will have the suppuratives - the liquefied area becomes a cystic space

Question 10

• At high magnification, liquefactive necrosis of the brain demonstrates

Answer 10

many macrophages which are cleaning up the necrotic cellular debris

Question 11

The job description of a macrophage includes _____particularly when there is lipid debris

Answer 11

janitorial services

Question 12

a liquefactive necrosis in liver shows which wbc

Answer 12

neutrophil

Question 13

inflammatory cells in acute inflammatopn

Answer 13

neutrophil

Question 14

a Caseous necrosis will demonstrae

Answer 14

granuloma with central necrosis in a lung of a person with
tubercylosis

Question 15

a cell predominant in caseous necrosis

Answer 15

Langhans-type giant cells

Question 16

the Langhans-type giant cells (with many nuclei arranged in a ___like pattern at the edge of the cell) around the periphery of the granuloma

Answer 16

horseshoe

Question 17

Langhans-type giant cells are seen in many types of ___ and are not
specific for tuberculosis

Answer 17

granulomas

Question 18

. It is also a distinctive
form of coagulative necrosis. The
dead tissue appears as a soft and
white proteinaceous dead cell mass.

Answer 18

Caseous necrosis or caseous
degeneration

Question 19

Caseous necrosis or caseous
degeneration is a unique form of
cell death in which the tissue
maintains a ____appearance.

Answer 19

cheese-like

Question 20

Fibrinoid necrosis is a specific
pattern of irreversible, uncontrolled
cell death that occurs when
_____ are
deposited in the walls of blood
vessels along with fibrin.

Answer 20

antigen-antibody complexes

Question 21

Fibrinoid, When stained with hematoxylin and
eosin, they appear ____ and ___

Answer 21

brightly eosinophilic and smudged.

Question 22

traumatic fat necrosis are significant only because _____

Answer 22

it produces a mass

Question 23

a morphology of fat necrosis mass in early stage

Answer 23

tender and sharply localized lesion

Question 24

a morphology of fat necrosis mass in late stage

Answer 24

ill-defined indurations (scar); may cause skin retraction

Question 25

microscopically, that is the characteristic of traumatic fat necrosis

Answer 25

a central focus of necrotic fat cells surrounded by neutrophil and lipid-filled macrophages, which is later enclosed by fibrous tissue and mononuclear leukocytes

Question 26

a fat necrosis wherein a multinucleated giant cells are frequently seen at this stage

Answer 26

intermediate stage of fat necrosis

Question 27

this fat necrosis stage shows an abundant infiltrate of _____ n response to necrotic adipocytes

Answer 27

lipid-laden histiocytes

Question 28

fat necrosis later will develop ___

Answer 28

scarring fibrosis

Question 29

____ may be defined as the reaction of vascularised living
tissue to local injury

Answer 29

Inflammation

Question 30

a type of inflammation wherein it’s gradual and less sever in onset

Answer 30

chronic inflammation

Question 31

a type of inflammation that is may be a consequence of a previous acute inflammation

Answer 31

Chronic inflammation

Question 32

Microscopically what we can observed in the inflammation

Answer 32

the chronically inflamed tissue accumulates lymphocytes at the site of the injury.

There is also a characteristic
proliferation of connective tissue

Question 33

is characterized by the
outpouring of a watery, relatively protein-poor fluid that, depending on the site of injury, derives either from the plasma or from the secretions of mesothelial cells lining the peritoneal, pleural, and pericardial cavities

Answer 33

Serous inflammation

Question 34

The skin blister resulting from a burn or viral infection is a good example of the accumulation of a ___ either within or immediately beneath the epidermis of the skin

Answer 34

serous effusion

Question 35

Fluid in a serous cavity is called an ___

Answer 35

effusion

Question 36

____ occurs as a
consequence of more severe injuries, resulting in greater vascular permeability that allows large molecules (such as fibrinogen) to pass
the endothelial barrier

Answer 36

Fibrinous inflammation

Question 37

Histologically, the accumulated extravascular fibrin appears as an ___

Answer 37

eosinophilic meshwork of
threads or sometimes as an amorphous coagulum

Question 38

A fibrinous exudate is characteristic of
inflammation in the lining of body cavities, such
as the ___, ___, and ____

Answer 38

meninges, pericardium, and pleura.

Question 39

_____ is inflammation of prolonged duration (weeks to years) in which continuing inflammation, tissue injury, and healing, often by fibrosis, proceed simultaneously.

Answer 39

Chronic inflammation

Question 40

chronic inflammation is characterized by

Answer 40

different set of reactions such as

—Infiltration with mononuclear cells, including macrophages, lymphocytes, and plasma cells

— Tissue destruction, largely induced by the products of the inflammatory cell

Question 41

in acute inflammation, it is characterized by

Answer 41

vascular changes, edema, and a predominantly neutrophilic infiltrate

Question 42

H&E preparations some of the activated
macrophages in granulomas have pink, granular
cytoplasm with indistinct cell boundaries; these
are called ___ because of their
resemblance to epithelia.

Answer 42

epithelioid cells

Question 43

aggregates of lymphocytes, what type of inflammation

Answer 43

granuloma of chronic inflammation

Question 44

multinucleate giant cells___ μm in diameter are found in granulomas.

Answer 44

40 to 50