L7: Structure and Function of Immune system Flashcards
what are the central lymph organs ?
bone marrow and thymus
what are the peripheral lymph organs ?
spleen , lymph nodes , and MALT
WHERE ARE ALL CELLS DESITNED TO BE IMMUNE CELLS PRODUCED?
bone marrow
what does becoming immunocompetent mean ?
cell bearing antigen receptors and CD proteins
what’s the largest lymph organ ?
slpeen ,
where in the spleen is lymph tissue present?
white pulp
what distinguishing marker is present on the cell surface of T-cells?
CD marker
helper CD4 T-cells are essential in activation of ___
of B-cells , T-cells , NK Cells and macrophages
what cells are responsible for graft rejection ?
CD8 cytotoxic T-cells
non-self immune system recognizes foreingness by means of____
epitopes on antigen surface
how does the body distinguish self cells from non self cells>?
presence of MHC
MHC 1 is present in____
all nucleated cells
MHC2 is present on ____
Antigen-presenting cells
MHC is determined by ____
HLA genes
what makes NK cells unique ?
they do not need to recognize a specific antigen on a cell to kill it
NK cells constitute only 10% of lymphocyte count
they supress tumors and protect body against wide variety of infectious microbes
What’s the most important leukocyte ?
monocyte
what cell is responsible for first response ?
neutrophils
what are TCR receptors on T-cells?
receptors made of beta and alpha chains
what type of cells are responsible for destroying intra-cellular pathogens ?
CD8 cytotoxic T-cells (cell mediated immunity)
what cells are responsible for extra-cellular pathogen destruction?
B cells ( humoral immunity)_
what antibody has the highest concentration in blood?
Ig G in chronic infection
what antibody increases in case of allergies ?
Ig E
when antigen is presented alongside MHC I , which cells bind?
cytotoxic CD8 T cells
when antigen is presented alongside MHCII , which cell binds?
Helper CD4 T cells
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