L7: Structure and Function of Immune system

Question 1

what are the central lymph organs ?

Answer 1

bone marrow and thymus

Question 2

what are the peripheral lymph organs ?

Answer 2

spleen , lymph nodes , and MALT

Question 3

WHERE ARE ALL CELLS DESITNED TO BE IMMUNE CELLS PRODUCED?

Answer 3

bone marrow

Question 4

what does becoming immunocompetent mean ?

Answer 4

cell bearing antigen receptors and CD proteins

Question 5

what’s the largest lymph organ ?

Answer 5

slpeen ,

Question 6

where in the spleen is lymph tissue present?

Answer 6

white pulp

Question 7

what distinguishing marker is present on the cell surface of T-cells?

Answer 7

CD marker

Question 8

helper CD4 T-cells are essential in activation of ___

Answer 8

of B-cells , T-cells , NK Cells and macrophages

Question 9

what cells are responsible for graft rejection ?

Answer 9

CD8 cytotoxic T-cells

Question 10

non-self immune system recognizes foreingness by means of____

Answer 10

epitopes on antigen surface

Question 11

how does the body distinguish self cells from non self cells>?

Answer 11

presence of MHC

Question 12

MHC 1 is present in____

Answer 12

all nucleated cells

Question 13

MHC2 is present on ____

Answer 13

Antigen-presenting cells

Question 14

MHC is determined by ____

Answer 14

HLA genes

Question 15

what makes NK cells unique ?

Answer 15

they do not need to recognize a specific antigen on a cell to kill it

Question 16

NK cells constitute only 10% of lymphocyte count

they supress tumors and protect body against wide variety of infectious microbes

Question 17

What’s the most important leukocyte ?

Answer 17

monocyte

Question 18

what cell is responsible for first response ?

Answer 18

neutrophils

Question 19

what are TCR receptors on T-cells?

Answer 19

receptors made of beta and alpha chains

Question 20

what type of cells are responsible for destroying intra-cellular pathogens ?

Answer 20

CD8 cytotoxic T-cells (cell mediated immunity)

Question 21

what cells are responsible for extra-cellular pathogen destruction?

Answer 21

B cells ( humoral immunity)_

Question 22

what antibody has the highest concentration in blood?

Answer 22

Ig G in chronic infection

Question 23

what antibody increases in case of allergies ?

Answer 23

Ig E

Question 24

when antigen is presented alongside MHC I , which cells bind?

Answer 24

cytotoxic CD8 T cells

Question 25

when antigen is presented alongside MHCII , which cell binds?

Answer 25

Helper CD4 T cells

Question 26

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Answer 26

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