L26-27 DNA and RNA viruses Flashcards
which viral infection causes oral sqamous papilloma / squamous cell carcinoma (verrucous carcinoma ?
papovaviruses
what is the shape of papovaviruses ?
icosahedral
how are papovaviruses transmitted ?
through direct contact or autoinoculation
how are adenoviruses spread?
respiratory and ocular secretions
what does an adenovirus infection cause ?
acute respiratory disease , pharyngitis , and conjunctivitis
herpes family of viruses include :
herpes simplex 1 and 2
varicella zoster virus
epstein barr virus
cytomegalo virus
human herpes virus 6,7,8
what does a herpes simplex 1 viral infection cause ?
acute gingivastomatitis : painful vascular lesions on gums , lips , and oral mucosa
herpatic kertoconjuctivitis
encephalitis
herpatic witlow
herpes simplex 2 infection causes:
genital herpes
aseptic meningitis
neonatal herpes
what does varicella-zoster infection result in ?
varicella (chickenpox) : primary infection usually in childhood)
zoster ( shingles) : reactivation of earlier varicella
how is a zoster infection different from varicella ?
shingles rash is similar to varicella but it is limited to skin innervated by a dorsal root ganglia (usually trigeminal)
what smear is used in order to see multinucleated giant cells in varicella-zoster infection?
tzank smear
PCR in screening for varicella-zoster virus looks for viral DNA in the ____
CSF
Which viral infection is characterized by lymphocytosis ?
Epstein barr virus
which viral infection is associated with human malignancies such as Burkits lymphoma , nasopharengeal carcinoma and oral hairy leukoplakia ?
Epstein barr virus
the latent form of epstein barr virus is present within ____
lymphocytes , B cells
high risk groups for symptomatic cytomegalovirus infection:
HIV / AIDS patients
organ transplant recipients
fatal to newborns if acquired congenitally
which viral infection has an owl eye apperance under the microscope?
cytomegalovirus
which lymphocytes does human herpes virus 6 have affinity to?
both B and T cells
which viral presence is usually asymptomatic in healthy adults ?
cytomegalovirus
what diseases can be cause by human herpes virus 6?
mononucleosis with cervical lymphadenopathy
exanthem subitum (roseola infantum )
human herpes virus 6 is present in :
saliva of most healthy adults
what is HHV-7 associated with ?
rashes
which lymphocytes are affected by HHV-7 ?
T cells
which virus is associated with kaposis sarcoma ?
HHV-8
Also associated with vascular endothelial tumor which is common in HIV patients
which group of viruses is responsible for influenza infection ?
orthomyxovirus
orthomyxoviruses are subdivided into types A, B , and C based on :
nucleocapsid protein NP and
viral envelope matrix protein :protein M
nomenclature of influenza viruses is based on :
hemogglutanin (H) and neuriminidase (N)
which viruses have a spherical structure and segmented , 8 piece ssRNA (capable of genetic re-assortment ?
orthomyxoviruses
which group of viruses includes mumps , measles and parainfulenza , RESPARITORY syncytial virus ?
paramyxoviruses
describe the structure of paramyxoviruses :
pleomorphic
Single linear ssRNA
influenza virus
possesses:
nucleocaspid shape:
transmission :
RNA polymerase
helical
respairatory aerosols
what is the difference between antigen shift and antigen drift?
antigen shift is a major re-assortment of RNA segments while Antigen drift is a minor change or mutation in the RNA
what diseases are caused by resparatory syncytial virus ?
pneumonia and bronchitis in infants
otitis media in children
what diseases are caused by resparatory syncytial virus ?
pneumonia and bronchitis in infants
otitis media in children
what are the complications of mumps viral infection ?
paratitis in one of or both parotid glands
attenuated form of which virus is used in the measles mumps rubella vaccine ?
mumps virus
what are the complications of measles ?
respiratory issues
neurological issues
gangrenous stomatitis and noma –> can lead to destruction of orofacial tissue and consequent disfigurement when paired with necrotizing ulcerative gingivitis , malnutrition and oral ulcers
rash
rna virus = helical
dna virus = sphere
papillovirus : unenveloped
herpes: enveloped
orthomyxovirus : sphere
corona virus : enveloped
.
group A coxsackie viruses cause:
herpangia : herpes like oropharengitis
hand food , and mouth disease
what is the receptor for SARS coronavirus on the surface of cells ?
angiotensin converting enzyme 2
pneumonia caused by SARS is charecterized by
diffuse edema resulting in hypoxia
MERS is caused by MERS-CoV : BINDS TO cd26
