L11:Autoimmunity Flashcards
what are altered antigens known as?
neoantigens
what can stimulate polyclonal B cell activation ?
Lipopolysaccharide ( in cell wall of gram negative bacteria), chemical stimuli , and antibiotics and micro-organisms such as EBV
What is a common causative factor for molecular mimicry ?
infection by streptococci bacteria
what cells are enhanced and what cells have decreased function when there is a breakdown of immunological homeostasis ?
T helper cells are enhanced and regulatory T cells have decreased function
which IL do regulatory T cells secrete in order to inhibit proinflammatory Th-1 cells?
IL-10
autoimmunity against which cells is Present in insulin dependent DM ?>
ISLETS OF LANGERHANS IN PANCREASE
Addison’s disease involves autoimmunity against which type of cells?
cells of zona golmerulosa layer of adrenal gland
hashimotos thyroditis causes ___
thyrotoxicosis _____
hypothyroidism ( rugged inflammation and enlargement of gland )
hyperthyroidism ( graves disease ), formation of antibodies against thyroglobulin
what circulating auto-antibody is present in rheumatoid arthritis ?
Rheumatoid factor ( IgM Directed against IgG )
antibodies against what structure are produced in systemic lupus ?
cell nuclei ,Ig , organ specific antigens ,
what oral manifestations are presented in systemic lupus ?
genitival bleeding, gingivitis , and petechial legions , mucosal lesions
what genes can predispose a person to systemic lupus ?
HLA-DR2 , and DR3
What does sjogrens syndrome affect ?
salivary and lacrimal glands
what does pemphigus vulgaris affect ?
chronic condition affecting skin and mucosa
what antibodies are produced in pemphigus vulgaris ?
IgG Against desmosomal components
