L1: Anatomy of The Thyroid Gland Flashcards
The thyroid gland starts functioning from the β¦β¦ month of intrauterine life.
4th
The thyroid gland is derived from β¦β¦.
- Thyroglossal duct.
- Ultimobranchial body.
- Neural Crest Cells
Origin of Thyroglossal Duct
From the endoderm of the floor of the embryonic pharynx at the foramen cecum.
What is Foramen Cecum?
A midline foramen at the junction of the anterior 2/3 & posterior 1/3 of the developing tongue.
Course of Thyroglossal Duct
Fate of Thyroglossal Duct
Derivateves of Thyroglossal Duct
- The bilobed lower end of the thyroglossal duct gives origin to the follicular cells of the thyroid gland.
Derivatives of Ultimobronchial Body
βCaudal pharyngeal complexβ
Joins each side of the lower end of thyroglossal duct to give origin to parafollicular cells.
Congenital Anomalies of Thyroid Gland
- Ectopic thyroid
- Thyroglossal cyst
- Thyroglossal fistula
what causes ectopic thyroid?
- The thyroglossal duct fails to descend
Site of ectopic thyroid
What causes thyroglossal cyst?
- Persistence of thyroglossal duct
Site of thyroglossal cyst
Presents as midline swelling in the neck.
- Usually it is found in the vicinity of the hyoid bone, So during surgical removal of the cyst the body of hyoid bone is also removed to prevent recurrence.
What causes Thyroglossal fistula?
When the cyst breaks through the skin
- Never congenial
The thyroid gland is a β¦β¦ vascular endocrine gland
highly
Site of Thyroid Gland
Lower part of the front of the neck βin close relation to larynx & tracheaβ
Average Weight of Thyroid Gland
= 25 gm in adult βSlightly heavier in femaleβ
Parts of Thyroid Gland
Extent of Thyroid Gland
Capsule of Thyroid Gland
Has a true capsule (fibrous) and a false capsule (fascial).
Enlarged thyroid gland shifted downward not upward
why?
- The upward shift: is arrested by the attachment of sternothyroid muscle to the oblique line of thyroid cartilage.
- The downward shift: The short neck & strong strap muscles are responsible for pushing the lower pole of a normally located but enlarged gland downward into the superior mediastinum (retrosternal goiter).
what are types of thyroid capsules?
- True capsule (fibrous)
- False capsule (fascial)
Describe True Capsule of Thyroid Gland
- The condensation of the connective tissue at the periphery of the gland
- Completely surrounds the gland.
- The venous plexus lies deep to the true capsule.
Clinical Correlation related to True Capsule of Thyroid Gland
- During surgical removal of the gland, care is taken to remove the gland along with its true capsule to avoid injury to venous plexus.
what is the False capsule (fascial) of thyroid gland derived from?
- Derived from the pretracheal layer of deep cervical fascia.
Attachment of pretracheal fascia
Importance of pretracheal fascia
Responsible for movement of the thyroid gland up with deglutition.
Clinical Correlations of Pretracheal fascia
- Movements of the thyroid during swallowing (deglutition) & speech: due to the attachments of the pretrachel fascia to (Thyroid & cricoid cartilages + Hyoid bone).
- Retrosternal extension.
- Compression manifestation of huge goitre.
- Suspensory ligament of Berry
Definition of Suspensory ligament of Berry
A thickening of pretracheal fascia.
Site of Suspensory ligament of Berry
Between Posteromedial aspect of thyroid gland lobe & cricoid cartilage.
Importance of Suspensory ligament of Berry
Each lobe of thyroid gland presents the following
Relations of Superficial surface of thyroid gland
Relations of Medial surface of thyroid gland
Relations of Posterior surface of thyroid gland
Relations of Anterior Border of thyroid gland
- Related to: The anterior branch of the superior thyroid artery.
Relations of Posterior Border of thyroid gland
Related to:
- The parathyroid glands.
- The anastomosis between the superior & inferior thyroid arteries.
Anterior Relations of the Isthmus
Posterior Relations of the Isthmus
It rests on 2nd to (3d or 4th) tracheal rings.
Relations to the upper margin of the isthmus
The terminal parts of anterior branches of both superior thyroid arteries
- Take part in a rich anastomosis, which supply twigs to the anterior surface of the isthmus also.
Relations to the Lower margin of the isthmus
- The inferior thyroid veins emerge.
- The thyroidea ima (when present) enters.
These vascular relations of the isthmus are to be kept in mind during tracheostomy.
Relations to the Apex of thyroid Gland
- limited by the insertion of the thyrohyoid muscle to the oblique line of the thyroid cartilage.
- It is related to:
- The superior thyroid artery.
- External laryngeal nerve.
Relations to the Base of thyroid Gland
Related to:
- Inferior thyroid artery.
- Recurrent laryngeal nerve.
- On the left side, it may be related to the arch of the thoracic duct.
How to find the thyroid gland lobes?
How to find the thyroid gland isthmus?
Arterial Supply of Thyroid Gland
- Pair of Superior thyroid arteries
- Pair of inferior thyroid arteries
- The thyroidea ima
- The accessory thyroid arteries.
Where Does the Superior Thyroid Artery Arise from?
External carotid artery
Course of Superior Thyroid Artery
Where do Inferior Thyroid Arteries arise from?
The thyrocervical trunk of the first part of subclavian artery
Course of Inferior Thyroid Arteries
The β¦β¦ branch of the inferior thyroid artery anastomoses with the β¦β¦. branch of the superior thyroid artery along the posterior margin of the gland.
ascending - descending
While tying the branches of inferior thyroid artery, its ascending branch supplying the parathyroid glands is always preserved, since it is the main supply of the parathyroid glands.
..
Where does The thyroidea ima arise from?
Arch of aorta or Brachiocephalic trunk
Course of The thyroidea ima
Ascends in front of the trachea & enters the isthmus.
Where do The accessory thyroid arteries arise from?
Twigs from esophageal & tracheal branches of inferior thyroid arteries.
The thyroid arteries are large-sized and show arterial loops to accommodate the upward & downward movements of the thyroid gland.
..
Venous Drainage of Thyroid Gland
Kocherβs Vein
- Site
- Opens
- Between the inferior & middle thyroid veins.
- Opens into the internal jugular vein.
Lymphtic Drainage of Thyroid Gland
Lymphatic spread of papillary carcinoma of the thyroid gland manifests in an interesting way.
Why?
- As the thyroid gland looks normal.
- But the deep cervical LNs of the jugular chain is enlarged & contains thyroid tissue.
NUCLEAR SCAN OF THYROID GLAND
Study Goiter from Notes
..
Def of Thyroid Stimulating Abs
- A family of IgG immunoglobulins.
- Collectively known as Thyroid Stimulating Antibodies (TsAB).
MOA of Thyroid Stimulating Abs
Def of Thyroid Follicles
The structural & functional unit of the thyroid gland.
General Characters of Thyroid Follicles
Cells Lining the Thyroid Follicles
Thyroid Hormone Synthesis