Kinetics of Ab Responses Flashcards
Lag Phase
Ag capture & presentation to B cell, activation of B cells, proliferation, differentiation
Temporal Phases
Lag Phase, Log Phase, Plateau, Decline
Log Phase
rapid production of Ab by plasma cells
Plateau phase
as Ag is eliminated, Ab production wanes & is balance by utilization or decay
Decline Phase
Abs have half-life of up to 28 days & w/o production, Ab levels decline
Secondary Response vs. Primary Response Kinetics
Secondary develops more rapidly than primary
Secondary Response vs. Primary Response magnitude
Secondary is greater than primary
Ab class primary response
IgM first
IgG, IgA, IgE later
Ab class secondary response
IgG, IgA, IgE first
IgM later w/ same kinetics as primary response
Secondary response vs. Primary response Ab affinity for Ag
Secondary response Abs have greater affinity than primary response abs
Secondary Response vs Primary Response TCR affinity for Ag
no change!
TCRalpha-beta doesn’t undergo somatic hypermutation
Synonym for Secondary Response
anamnestic response
(not forgetting response)
AKA memory
IgM’s vs IgG’s affinity
IgM’s stays relatively low over time.
IgG’s increases over time
Secondary Response’s lag phase is…
shorter than primary response’s
T cell Kinetics
pretty much the same as B-cell kinetics
