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Immunology > Cells & Tissues of the Immune System > Flashcards

Cells & Tissues of the Immune System Flashcards

0
Q

Types of T cells

A

Tgamma-delta, Talpha-beta

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1
Q

Lymphocytes

A

B lymphocytes

T lymphocytes

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2
Q

Types of Talpha-beta cells

A

CD4 => Th1, TH2, TH17, Tfh, Treg

CD8

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3
Q

T cell surface markers

A

CD4, CD8, CD3

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4
Q

B cell surface markers

A

CD79

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5
Q

B cell function

A

secrete Abs

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6
Q

B cell Ag Receptor

A

membrane form of Ig (IgM or BCR)

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7
Q

B cell location in secondary lymphoid tissues

A

follicles (nodules)

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8
Q

general helper T cell functions

A

help adaptive immune responses by activating other cells

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9
Q

Th1 function

A

activate macrophages

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10
Q

Th2 function

A

activate eosinophils

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11
Q

Th17 function

A

activate neutrophils

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12
Q

Tfh function

A

activate B cells

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13
Q

Treg function

A

inhibit adaptive immune responses & help avoid immune responses to “self” Ags

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14
Q

Tc function

A

kill cells that express Ags of intracellular pathogens

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15
Q

T cell Ag receptor

A

TCR

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16
Q

Location of T cells in secondary lymphoid tissues

A

diffuse tissue

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17
Q

Types of Primary Lymphoid Tissues

A

bone marrow, thymus, cloacal bursa, ileal Peyer’s patches

18
Q

Primary Lymphoid Tissue def.

A

where lymphocytes mature from precursor cells

19
Q

Where do all lymphocytes originate from precursors in?

A

bone marrow

20
Q

T cells mature in

A

the thymus

21
Q

B cells mature in the

A

cloacal bursa, ileal Peyer’s patches, bone marrow

22
Q

Secondary Lymphoid Tissue def

A

where mature lymphocytes encounter Ag & are activated in adaptive immune responses.

23
Q

Types of Secondary Lymphoid Tissues

A

spleen, lymph nodes, Mucosa-Associated Lymphoid Tissues (tonsils, intestinal Peyer’s patches, lymph nodes draining mucosal tissues)

24
Q

Function of secondary lymphoid tissues

A

filter foreign antigens

25
Q

spleen filters

A

blood-borne antigens

26
Q

Mucosa-Associated Lymphoid Tissues (MALT) filter

A

Ags entering at mucosal surfaces

27
Q

Lymph Nodes filter

A

Ags in any tissue that it drains

28
Q

Mucosal Immune System lymphoid tissues are

A

different than other lymphoid tissues

29
Q

Anatomic features of mucosal immune system

A
  • intimately associated with epithelium

- specialized Ag uptake mechanisms (M cells)

30
Q

Effector mechanisms of mucosal immune system

A
  • Activated/memory T cells predominate
  • Activated Treg cells present
  • Secretory IgA
  • Distinctive microbiota
31
Q

Immune regulation of mucosal immune system

A
  • active suppression predominates (food)

- inhibitory macrophages & DCs

32
Q

Naive lymphocytes

A

lymphocytes that haven’t previously recognized Ags & been activated

33
Q

naive lymphocytes circulation patterns

A

circulate between blood and secondary lymphoid tissues

34
Q

How do lymphocytes enter the spleen from the bloodstream?

A

directly via the blood

35
Q

How do lymphocytes enter lymph nodes & Peyer’s patches from the blood stream?

A

via venules with specialized endothelial cells in diffuse tissue

36
Q

How do Ags & DC carrying Ags move from infected tissue to lymph nodes?

A

via lymphatic vessels

37
Q

Mucosal lymphatic tissues get Ags and DC from..

A

mucosal surface and lamina propria

38
Q

memory lymphocytes circulation pattern

A

tend to return to type of lymphoid tissue where they were first activated

with minimal cross-over

39
Q

mucosal infection vaccines (resiratory, GI)

A

provide better local immunity if given at mucosal site but have shorter duration of immunity compared to systemically administered vaccines

40
Q

Effector B cell circulation patterns

A

migrate from follicular tissues into medullary cords (lymph nodes), red pulp (spleen), lamina propria (mucosal-associated lymphoid tissue) or bone marrow.

41
Q

where is most plasma cell IgG production done?

A

bone marrow

42
Q

Effector T cell circulation patterns

A

migrate from lymphoid tissues into infected tissues, where they’re needed to do their effector functions

Immunology (19 decks)

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