Immune Tolerance

Question 0

Peripheral Tolerance

Answer 0

tolerance established in secondary lymphoid tissues.

occurs because central tolerance is imperfect & allows some self-reactive lymphocytes to mature

Question 1

Central Tolerance

Answer 1

tolerance established in primary lymphoid tissues by negative selection

Question 2

What are the types of self tolerance?

Answer 2

1. Central Tolerance

2. Peripheral Tolerance

Question 3

Immunologic Tolerance

Answer 3

failure of immune system to respond to an antigen.

Question 4

where do we mostly see immunologic tolerance?

Answer 4

in dogs!! occasionally in cats/horses. never in ruminants

Question 5

Immunologic Ignorance

Answer 5

occurs when self antigens don’t enter 2ndary lymphoid tissues in sufficient concentrations to activate CD4 cells

Question 6

Activation-Induced Cell Death occurs when..

Answer 6

Autoantigens are present in very high concentrations and can activate lymphocytes.
The repeated activation of lymphocytes causes this reaction via apoptosis.

Question 7

Induced Anergy is

Answer 7

a state of non-responsiveness to Ag.

Question 8

Induced Treg Cell Differentiation occurs when

Answer 8

CD4 cells recognize Ag in the absence of costimulatory signals