Journal Education

Question 1

metabolite of bupe

Answer 1

norbuprenorphine

Question 2

treatment for cannabis cravings

Answer 2

gabapentin
NAC

Question 3

therapeutic dose of methadone

Answer 3

80-120 mg

Question 4

Meth craving treatments

Answer 4

Vivitrol + Bupropion 450mg XL
Mirtazapine
Stimulants??

Question 5

Cocaine craving treatments

Answer 5

Topiramate 300mg
Bupropion 300 mg
Modfinil 200-400 mg
D-amphetamine 60 mg

Question 6

mild vs moderate vs severe CIWA scores

Answer 6

Mild: <8-10
Moderate 10-15
Severe: >15

Question 7

Timeline of mild vs moderate withdrawal

Answer 7

Mild: 6-24 hrs
Moderate: 24-72 hrs

Question 8

mild vs moderate withdrawal symptoms

Answer 8

Mild: anxiety, tremor, HA, GI, insomnia, tachycardia

Moderate: Agitation, diaphoresis, tachycardia, hyperthermia

Question 9

timeline of alcoholic hallucinosis

Answer 9

12-24 hrs, resolve by 48 hrs

Question 10

timeline of DTs

Answer 10

72-96 hrs, and last 2-3 days

Question 11

DT sxs

Answer 11

VH, disoriented, tachycardia, HTN, diaphoresis, agitation, fever, MI/arrythmias

Question 12

opioid receptor is what type of receptor

Answer 12

G-coupled protein receptor

Question 13

increase or decrease when opioid receptor gets activated: cAMP, Ca influx, K efflux, MAP kinase signaling

Answer 13

cAMP - down
Ca influx - down
K efflux - up
MAP kinase signaling - up

Question 14

5 contraindications for topiramate

Answer 14

Kidney stones
Abnormal GFR
Metabolic acidosis
Acute narrow angle glaucoma
SI as prior ran