15 Flashcards
Side effects to naltrexone
nausea
anorexia
abdominal pain
fatigue, insomnia, daytime sleepiness
headache
reversible hepatotoxicity
in odds ratio, if the confidence interval crosses ____, then it’s not statistically significant
1
which gene involved with increased risk of smoking and interaction with pharmacotherapy in smokers?
CHRN5
mean treatment length for detox inpatient vs outpatient
outpatient - 6.5 days
Inpatient - 9.2 days
when should phenobarbital be used for neonatal abstinence syndrome?
seizures
polydrug withdrawal
non-opiate withdrawal
received max of opium
peak euphoric effect from marijuana inhaled at
30 min
probability of becoming dependent on tobacco after one use?
32%
NIDA quick screen is how many questions?
one
NSAIDs can be false positive for
marijuana
is genetic transmission of SUDs mendelian pattern?
no
does zidovudine have an effect on methadone levels?
no, just other way around
which gene is involved with people who get respiratory depression from codeine (and have european ancestry)?
CYP2D6
nicotine metabolized by
CYP2A6
do black people or white people absorb more nicotine?
black people - 30% more
which ethnicity have lower clearance of nicotine compared to white people?
asians - slower CYP2A6 metabolism
volume of distribution of smoking tobacco
180L
are benzos CYP 450 inducers?
no
how long is duration of cocaine when smoked versus snorted?
smoked: 20-30 min
snorted: 1-3 hours
what is this disorder - memory loss, confusion, drowsiness, poor balance, loss of spontaneity
Wernicke-Korsakoff
SSRI risk on fetus
pulmonary hypertension and withdrawal
men or women more likely to develop alcohol dependence?
men
MDMA metabolized by to form HHMA
CYP2D6
amphetamines excerpted via
urine - renal pathway
benadryl can be false positive for
opiates
mutated CHRN5 gene leads to ______ risk of tobacco dependence and ______ risk of cocaine dependence
increased - tobacco
decreased - cocaine
can end stage liver dz cause pinpoint pupils?
yes
70% of people with AUD will recover on their own without help after single drinking period lasting _____
3-4 years
cocaine half life
1 hour
