4 Flashcards
dynorphins bind to which opioid receptor and causes what
kappa –> dysphpria, decreased dopamine
12 mo prevalence of nicotine use disorder in US
20%
time to peak plasma concentration and time to peak effect for IV meth use vs smoking meth vs intranasal vs oral
IV: 15 min for both
smoking: 2.5 hrs for conc, 18 min for peak effect
intranasal: 3 hrs, 15 min for effect
oral: 3.5 hr (for both)
sertraline is false positive for
benzos
what features of urine would you look at to see if its been adulterated
- nitrites
- pH
what features of urine would you look at to see if its been diluted
- creatinine
- specific gravity
if someone on methadone needs acute pain management what do you do?
give them another opioid for acute pain management
dose of IM naltrexone
380 mg q4 weeks
how long is duration of cocaine?
30-60 minutes
12 month prevalence of AUD
13%
how does topiramate work to help reduce alcohol use?
antagonizes glutamate –> suppressed dopamine release in NA –> reduces reward
miscarriage is a possible withdrawal complication from…
opioids
after how many hours after drinking can you give disulfiram?
12 hours
how long should you wait to drink after getting disulfiram?
2 weeks
binge drinking defined as
drinking so much w/in 2 hours that BAC reaches 0.08g/DL (typically, 4 drinks for women, 5 for men)
does alcohol use disorder severity correlate with their risk of remission?
no
do kids with FAS have a hard time making friends?
yes
are adults with FAS likely to be independent?
no
which endocrine disorders is associated with cigarette smoking?
Graves disease, hypogonadism, DM, SIADH
which endocrine disorder is associated with cocaine?
hyperprolactinemia
which endocrine disorder is associated with anabolic steroid use
gynecomastia
which endocrine disorder is associated with alcohol use d/o?
pancreatic insufficiency
among americans who use alcohol, what percent report heavy drinking?
12%
How defining heavy drinking
> 5 drinks on 5 days
among americans who use alcohol, what percent report binge drinking?
24%
which gene associated with higher cocaine addiction susceptibility
CAMK4
which gene associated with cocaine induced paranoia
VNTR
