11 Flashcards
D3 antagonists help substance use disorders how?
DAT blocker - methylphenidate analogue with slower onset of action
most common course for AUD In adults lasts how many years
3-4
MDMA full name
3,4-Methylenedioxymethamphetamin
EEG for chronic cocaine user
decreased delta and theta - drowsy
increased alpha and beta - alert
benefits of pregabalin to gabapentin
- quicker dose titration
- faster pain relief
- dosed BID not TID
what percent of people with schizophrenia abuse drugs?
60% (37% with SUD)
how many days of sobriety after opioid before getting naltrexone?
7-10 days
do you need dose adjustments for naltrexone in patients with hepatic dysfunction?
no
difference between prevalence and incidence
incidence: #new cases/population
prevalence: #people with dz/population at particular time pt
Motivational Enhancement Therapy (MET) gist
gives patients feedback on their substance use compared to a normative group
which class of meds to avoid in patients who have used cocaine and have ACS?
beta blockers
MDMA metabolized by
CYP2D6
half life of MDMA
8 hours
nitrite inhalants (aka poppers) MOA
peripheral vasodilation –> reduced cerebral perfusion
Dexmedetomidine (precedex) moa
alpha 2 rec agonist
which personality disorder most common with SUDs?
antisocial personality disorder
buprenorphine MOA at each opioid rec
partial agonist at mu
antagonist at kappa
which opioid receptor has highest abuse potential
mu
1mg of lorazepam is how much alprazolam and diazepam
0.5 mg alprazolam
5mg diazepam
proton pump inhibitors can cause false positive for what drug
marijuana
which arrhythmia is most common in heavy alcohol use?
atrial fibrillation
gene involved with efficacy of long-term methadone treatment
OPRD1
12 month prevalence of nonmedical prescription opioid use disorder
0.9%
