3 Flashcards
disulfiram blocks what enzyme
Aldehyde dehydrogenase
disulfiram blocking enzyme prevents what being converted to what
acetylaldehyde –> acetyl coenzyme A
minimum of THC mg that can cause delirium and myoclonic jerks
> 7.5mg ….sure….
hyperacusis is a withdrawal symptom of what drug
benzos
prevalence of cannabis use disorder or people >18 y/o is
1.5%
prevalence of cannabis use disorder or people 18-29%
4.4%
does extended release or short acting release opioids lead to higher risk of opioid misuse?
extended release
most effective therapy for addiction?
CBT
metabolites of disulfiram
carbon disulfide and acetone
rifampin is inducer or inhibitor of CYP3A4?
inducer
MATCH study summary
1990s study compared CBT, 12 step, and motivational enhancement therapy (MET) for AUD
- MET best for angry patients
- CBT better for less severe patients
- 12 step better for more severe patients, comorbid SUD, and less social support than CBT
what does Medical Review Officer do?
establishes whether or not there is a medical explanation for positive results
any treatment for FAS?
no….just life skills courses
what drug is leading cause of preventable death in the US?
tobacco
brain areas in initial part of addiction (binging and intoxication)
ventral striatum (including NA and olfactory tubercle) and ventral tegmentum (euphoria)
brain areas in middle part of addiction (withdrawal)
amygdala
brain areas in final part of addiction (preoccupation and anticipation)
hippocampus and prefrontal cortex
how to handle poor feeding of neonatal abstinence syndrome?
small frequent feeds of hyper caloric formula
Carisprodol (Soma) is concerning because
it potentiates effects of alcohol and opioids, increasing risk of overdose
families of opioid receptors
Endorphin - mu
Dynorphin - kappa
Enkephalin - delta
enkephalin - what type of opioid receptor and for what function
delta
pain perception
mescaline and other hallucinogen MOA
postsynaptic serotonin 2A agonists
nicotine receptor is pre or post synaptic
alpha 4 beta 2 post synaptic rec
