3

Question 1

disulfiram blocks what enzyme

Answer 1

Aldehyde dehydrogenase

Question 2

disulfiram blocking enzyme prevents what being converted to what

Answer 2

acetylaldehyde –> acetyl coenzyme A

Question 3

minimum of THC mg that can cause delirium and myoclonic jerks

Answer 3

> 7.5mg ….sure….

Question 4

hyperacusis is a withdrawal symptom of what drug

Answer 4

benzos

Question 5

prevalence of cannabis use disorder or people >18 y/o is

Answer 5

1.5%

Question 6

prevalence of cannabis use disorder or people 18-29%

Answer 6

4.4%

Question 7

does extended release or short acting release opioids lead to higher risk of opioid misuse?

Answer 7

extended release

Question 8

most effective therapy for addiction?

Answer 8

CBT

Question 9

metabolites of disulfiram

Answer 9

carbon disulfide and acetone

Question 10

rifampin is inducer or inhibitor of CYP3A4?

Answer 10

inducer

Question 11

MATCH study summary

Answer 11

1990s study compared CBT, 12 step, and motivational enhancement therapy (MET) for AUD

• MET best for angry patients
• CBT better for less severe patients
• 12 step better for more severe patients, comorbid SUD, and less social support than CBT

Question 12

what does Medical Review Officer do?

Answer 12

establishes whether or not there is a medical explanation for positive results

Question 13

any treatment for FAS?

Answer 13

no….just life skills courses

Question 14

what drug is leading cause of preventable death in the US?

Answer 14

tobacco

Question 15

brain areas in initial part of addiction (binging and intoxication)

Answer 15

ventral striatum (including NA and olfactory tubercle) and ventral tegmentum (euphoria)

Question 16

brain areas in middle part of addiction (withdrawal)

Answer 16

amygdala

Question 17

brain areas in final part of addiction (preoccupation and anticipation)

Answer 17

hippocampus and prefrontal cortex

Question 18

how to handle poor feeding of neonatal abstinence syndrome?

Answer 18

small frequent feeds of hyper caloric formula

Question 19

Carisprodol (Soma) is concerning because

Answer 19

it potentiates effects of alcohol and opioids, increasing risk of overdose

Question 20

families of opioid receptors

Answer 20

Endorphin - mu

Dynorphin - kappa

Enkephalin - delta

Question 21

enkephalin - what type of opioid receptor and for what function

Answer 21

delta

pain perception

Question 22

mescaline and other hallucinogen MOA

Answer 22

postsynaptic serotonin 2A agonists

Question 23

nicotine receptor is pre or post synaptic

Answer 23

alpha 4 beta 2 post synaptic rec